Purpose: To explore the reasons for poor multidisciplinary team (MDT) cooperation of Chronic Critical Illness (CCI) patients and their needs and expectations for carrying out MDT cooperation, with a view to providing references for improving MDT cooperation of CCI patients.
Methods: Semi-structured interviews with 15 members of the MDT of CCI patients in a hospital of Henan Province were conducted in September and October of 2024 using a descriptive qualitative design. The data were analyzed using the thematic analysis method developed by Braun and Clarke.
Results: Three themes emerged: Theme 1: The collaborative experience of MDT members, with three sub-themes: essential MDT cooperation, absence of specialized MDT, and the nurse's diminished role; Theme 2: Barriers to MDT cooperation, with three sub-themes: unclear cooperation process and job responsibilities, lack of effective communication, and insufficient observation and feedback; Theme 3: Facilitators to MDT cooperation, divided into three sub-themes: timely and effective communication, a leading role, well-developed MDT tools.
Conclusion: Due to the following deficiencies: unclear cooperation process and job responsibilities, lack of effective communication, and insufficient observation and feedback, it is urgent to take appropriate measures to promote MDT cooperation for CCI patients.
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http://dx.doi.org/10.2147/JMDH.S505022 | DOI Listing |
medRxiv
February 2025
Department of Population Health Sciences, University of Leicester, Leicester, UK.
Background: Idiopathic pulmonary fibrosis (IPF) is a rare, incurable lung disease with a median survival of 3-5 years after diagnosis. Treatment options are limited. Genetic association studies can identify new genes involved in disease that might represent potential new drug targets, and it has been shown that drug targets with support from genetic studies are more likely to be successful in clinical development.
View Article and Find Full Text PDFJ Multidiscip Healthc
February 2025
Department of Nursing, Henan Provincial People's Hospital, Zhengzhou, People's Republic of China.
Purpose: To explore the reasons for poor multidisciplinary team (MDT) cooperation of Chronic Critical Illness (CCI) patients and their needs and expectations for carrying out MDT cooperation, with a view to providing references for improving MDT cooperation of CCI patients.
Methods: Semi-structured interviews with 15 members of the MDT of CCI patients in a hospital of Henan Province were conducted in September and October of 2024 using a descriptive qualitative design. The data were analyzed using the thematic analysis method developed by Braun and Clarke.
Dev Cell
January 2025
Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:
Distinguishing tumor maintenance genes from initiation, progression, and passenger genes is critical for developing effective therapies. We employed a functional genomic approach using the Lazy Piggy transposon to identify tumor maintenance genes in vivo and applied this to sonic hedgehog (SHH) medulloblastoma (MB). Combining Lazy Piggy screening in mice and transcriptomic profiling of human MB, we identified the voltage-gated potassium channel KCNB2 as a candidate maintenance driver.
View Article and Find Full Text PDFNat Genet
January 2025
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
Transcription factors are frequent cancer driver genes, exhibiting noted specificity based on the precise cell of origin. We demonstrate that ZIC1 exhibits loss-of-function (LOF) somatic events in group 4 (G4) medulloblastoma through recurrent point mutations, subchromosomal deletions and mono-allelic epigenetic repression (60% of G4 medulloblastoma). In contrast, highly similar SHH medulloblastoma exhibits distinct and diametrically opposed gain-of-function mutations and copy number gains (20% of SHH medulloblastoma).
View Article and Find Full Text PDFMol Genet Genomics
December 2024
Center for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, 450052, Henan, China.
Given the high morbidity, mortality, and hereditary risk of cardiovascular diseases (CVDs), their prevention and control have garnered widespread attention and remain central to clinical research. This study aims to assess the feasibility and necessity of haplotyping-based preimplantation genetic testing for the prevention of inherited CVD. A total of 15 preimplantation genetic testing for monogenic defect (PGT-M) cycles were performed in 12 CVD families from January 2016 to July 2022.
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