AI Article Synopsis
- The study investigates the impact of various antidepressant medications on melatonin production in the pineal gland, aiming to use this as a screening tool for antidepressants.
- All six antidepressants tested were found to increase both blood and pineal levels of melatonin.
- The authors recommend that this melatonin test be used alongside traditional methods to better confirm the antidepressant effects.
Article Abstract
The authors measured the effect of different antidepressant drugs on the pineal production of melatonin in order to see if this test can be used in an antidepressants screening protocol. Six antidepressant drugs belonging to different pharmacologic classes have been tested. The results show that all the molecules used enhance the plasmatic and pineal concentration of melatonin. However the selectivity of this test must be reinforced by using classical methods for the detection of an antidepressant effect.
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