Objective: Impairment in personality functioning (PF) has been linked to a number of mental disorders, including eating disorders (EDs). However, the precise relationship between PF and symptom severity, as well as the potential impact on outcome, remains unclear. The study aimed to analyse the association of PF and its change with severity of ED symptomatology as well as outcome of hospital treatment.
Method: The sample consisted of 397 patients with EDs, treated in 19 university hospitals for Psychosomatic Medicine and Psychotherapy in Germany between 1/2019 and 12/2020. PF was measured with the Structure Questionnaire of the Operationalised Psychodynamic Diagnosis (OPD-SQ, short version), eating psychopathology with the ED examination questionnaire (EDE-Q). Outcome was defined as a change in the EDE-Q total score. We used Latent Change Score Modelling to analyse changes in ED pathology during treatment and a 1-year follow-up period.
Results: A higher level of impairment in PF at admission correlated with more eating psychopathology and a less favourable outcome. Additionally, greater improvement in PF correlated with greater improvements in ED symptomatology at discharge.
Conclusion: Impairment in PF needs to be part of diagnostic assessments and should be considered an important treatment target for psychotherapeutic interventions.
Trial Registration: The MEPP study was registered in the German Clinical Trials Register (DRKS, www.drks.de; ID: DRKS00016412).
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http://dx.doi.org/10.1002/erv.3183 | DOI Listing |
J Aging Health
March 2025
Department of Geriatrics, College of Medicine, Florida State University, Tallahassee, FL, USA.
ObjectivesThis study investigated the associations between Five-Factor Model personality traits and balance impairment and lower limb strength.MethodsMiddle-aged and older adults (Age range: 34-104 years; >27,000) from six large samples from the US and England were assessed for standing balance, lower limb strength, personality traits, sociodemographic, and health-related variables.ResultsHigher extraversion, openness, agreeableness, and conscientiousness were related to lower balance impairment risk and better lower limb strength.
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Doctor of Physical Therapy Program, Nova Southeastern University, Tampa Bay Regional Campus, Clearwater, FL 33759, United States.
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View Article and Find Full Text PDFHaematologica
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Division of Haematology and Haemostaseology, Department of Medicine I, Medical University of Vienna; Vienna.
Hemophilia is a rare X-linked bleeding disorder caused by mutations in the F8 or F9 gene (hemophilia A or B), leading to deficient factor VIII or IX proteins, respectively. Hemophilia-related complications caused by bleeding into the joints (the hallmark of hemophilia) and age-related comorbidities occur frequently and impact the functionality and quality of life of persons with hemophilia (PwH). Given the chronic nature of hemophilia, we hypothesized that hemophilia has an association with accelerated biological aging.
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View Article and Find Full Text PDFFront Immunol
March 2025
Sinopharm Dongfeng General Hospital (Hubei Clinical Research Center of Hypertension), Hubei Key Laboratory of Wudang Local Chinese Medicine Research, Hubei University of Medicine, Shiyan, Hubei, China.
Hypertension, a globally prevalent condition, is closely associated with T cell-mediated inflammatory responses. Studies have shown that T cells, by secreting pro-inflammatory cytokines such as interferon-gamma (IFN-γ), Interleukin-17 (IL-17), and Tumor necrosis factor-alpha (TNF-α), directly lead to vascular dysfunction and elevated blood pressure. The activation of Th1 and Th17 cell subsets, along with the dysfunction of regulatory T cells (Tregs), is a critical mechanism in the onset and progression of hypertension.
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