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Process optimization mitigated the retention loss of an Fc-fusion protein during ultrafiltration/diafiltration.
Biotechnol Prog
March 2025
Downstream Process Development (DSPD), WuXi Biologics, Shanghai, China.
In the downstream processing of antibody-based therapeutics, ultrafiltration/diafiltration (UF/DF) is commonly applied for concentration and buffer exchange in the final formulation. For a given molecule, various factors such as membrane type, feed flux, and transmembrane pressure (TMP) can significantly influence the performance of UF/DF, impacting yield, buffer exchange efficiency, and product quality. Conventional membrane pore size selection is based on product molecular weight to ensure high retention.
View Article and Find Full Text PDFDevelopment of a sample preparation and analysis method for therapeutic monitoring of diazepam and major metabolite in alcohol withdrawal syndrome treatment.
J Pharm Biomed Anal
March 2025
Department of Forensic Toxicology, Institute of Forensic Sciences, Ankara University, Ankara 06620, Turkiye. Electronic address:
Diazepam, a widely prescribed benzodiazepine, is frequently used for the management of alcohol withdrawal syndrome, anxiety, seizures, and muscle spasms. Its monitoring is critical due to its potential for abuse and the therapeutic importance of its metabolite nordiazepam. A sustainable and environmentally friendly high-performance liquid chromatography method was developed and validated for the quantification of diazepam and its active metabolite nordiazepam in human plasma samples.
View Article and Find Full Text PDFTemperature-Responsive Zwitterionic Polymers That Undergo UCST-Type Liquid-Liquid Phase Separation under Physiological Ionic Strength.
Langmuir
March 2025
Department of Chemistry and Materials Engineering, Kansai University, 3-3-35, Yamate-cho, Suita, Osaka 564-8680, Japan.
Associative phase separation (complex coacervation) in liquid-liquid phase separation (LLPS) involves the separation of multiple substances into concentrated and dilute phases by electrostatic interactions. Simple phase separation (simple coacervation) occurs when the hydrophilicity and hydrophobicity of a single molecule change dramatically in response to a specific stimulus. Simple coacervation arises from the lower critical solution temperature (LCST)- and upper critical solution temperature (UCST)-type phase separations in aqueous media containing temperature-responsive polymers.
View Article and Find Full Text PDF'We're all in this together': the protective role of belongingness in the contribution of moral injury to mental health among participants in Israel's civil protest movement.
Eur J Psychotraumatol
December 2025
The Lior Tsfaty Center for Suicide and Mental Pain Studies, Ruppin Academic Center, Emek Hefer, Israel.
Participating in long-term protests against government actions can affect protesters' mental health and expose protesters to potentially morally injurious events (PMIEs), such as the betrayal by leaders they once trusted. This study aimed to shed light on the potential psychological buffers against the deleterious effects of exposure to PMIEs of betrayal among protesters and to examine the moderating role of belongingness in the relationships between protesters' exposure to PMIEs and stress, PTSD and depression levels. The study sample comprised 4036 Israeli protesters (= 54.
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