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Maternal Hyperandrogenemia and the Long-Term Neuropsychological, Sex Developmental, and Metabolic Effects on Offspring.
Int J Mol Sci
February 2025
2nd Department of Obstetrics and Gynaecology, Aretaieio Hospital, School of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece.
Maternal hormonal and metabolic disorders, such as diabetes and obesity, can adversely affect the intrauterine environment, resulting in suboptimal fetal growth and an elevated risk of cardiovascular and metabolic diseases in the later life of the offspring. In this review, we examine the long-term impact of elevated maternal androgen levels during pregnancy on offspring. Maternal hyperandrogenemia is linked to various neurodevelopmental disorders, including attention-deficit/hyperactivity disorder, autism spectrum disorder, and anxiety-like behaviors, mediated by alterations in key brain regions responsible for emotion and cognition.
View Article and Find Full Text PDFExploring the Role of miRNA-101a in the Circulatory System's Adaptive Mechanisms in Hypertensive Disorders of Pregnancy.
Diagnostics (Basel)
February 2025
Department of Cardiology, Institute of Mother and Child, 01-211 Warsaw, Poland.
Hypertensive disorders of pregnancy constitute one of the principal reasons for maternal and perinatal morbidity and mortality worldwide. Identification of molecular mechanisms causing placental dysfunction resulting in gestational hypertension is crucial in the development of new methods of prevention and treatment. The aim of this case-control study was to assess changes in miRNA expression, and biomarkers such as NT-proBNP and galectin-3, in women with uncomplicated pregnancies and hypertensive disorders of pregnancy.
View Article and Find Full Text PDFExosomal-complement system activation in preeclampsia.
J Obstet Gynaecol Res
March 2025
Precision Medicine and Integrated Nano-Diagnostics (P-MIND) Research Group, Office of the Dean, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa.
Aim: Preeclampsia (PE) is a severe pregnancy-related disorder characterized by hypertension and multi-organ failure, primarily affecting the maternal vasculature and placenta. The aim of this review is to explain the molecular mechanisms behind PE by investigating the relationship between exosome release and complement activation, which could provide insight into potential therapeutic targets.
Methods: This review analyzes existing literature on the role of the complement system and exosomes in the pathophysiology of PE.
Microchimerism and pregnancy complications with placental dysfunction.
Semin Immunopathol
March 2025
Faculty of Medicine, University of Oslo, Oslo, Norway.
Cells cross the placenta during pregnancy, resulting in proliferation of semiallogeneic cells in the mother and fetus decades later. This phenomenon, termed microchimerism, is documented across mammalian species, implying an evolutionary benefit. Still, short- and long-term effects remain uncertain.
View Article and Find Full Text PDFWould internal iliac artery occlusion cause gestational hypertension in the following pregnancy? A population-based study from 2008 to 2017.
Taiwan J Obstet Gynecol
March 2025
Department of Gynecology and Obstetrics, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan; Department Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan; School of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan. Electronic address:
Objective: In animal models, internal iliac artery occlusion caused gestational hypertension; however, whether this phenomena occurs in humans is still unknown.
Materials And Methods: This retrospective cohort study used data from the Birth Certificate Application of Taiwan and linked to the National Health Insurance Research Database and Taiwan Maternal and Child Health Database from 2008 to 2017. Women who underwent internal iliac artery occlusion before pregnant were identified according to diagnosis and procedure codes.
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