Many studies have demonstrated spatial-numerical associations, but the debate about their origin is still ongoing. Some approaches consider cardinality representations in long-term memory, such as a Mental Number Line, while others suggest ordinality representations, for both numerical and non-numerical stimuli, originating in working or long-term memory. To investigate how long-term memory and working memory influence spatial associations and to disentangle the role of cardinality and ordinality, we ran three preregistered online experiments (N = 515). We assessed spatial response preferences for letters (which only convey ordinal but no cardinal information, in contrast to numbers) in a bimanual go/no go consonant-vowel classification task. Experiment 1 ('no-go' trials: non-letter symbols) validated our setup. In Experiments 2 and 3, participants learned an ordinal letter sequence prior to the task, which they recalled afterwards. In Experiment 2, this sequence was merely to be maintained ('no-go' trials: non-letter symbols), whereas in Experiment 3, it needed to be retrieved during the task ('no-go' trials: letters outside the sequence). We replicated letter-space associations based on the alphabet stored in long-term memory (i.e., letters earlier/later in the alphabet associated with left/right, respectively) in all experiments. However, letter-space associations based on the working memory sequence (i.e., letters earlier/later in the sequence associated with left/right, respectively) were only detected in Experiment 3, where retrieval occurred during the task. Spatial short- and long-term associations of letters therefore seem to coexist. These findings support a hybrid model that incorporates both short- and long-term representations, which applies similarly to letters as to numbers.
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Proc Jpn Acad Ser B Phys Biol Sci
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Laboratory for Sleeping-Brain Dynamics, Research Center for Idling Brain Science, University of Toyama, Toyama, Japan.
Over the past decades, the understanding of sleep has evolved to be a fundamental physiological mechanism integral to the processing of different types of memory rather than just being a passive brain state. The cyclic sleep substates, namely, rapid eye movement (REM) sleep and non-REM (NREM) sleep, exhibit distinct yet complementary oscillatory patterns that form inter-regional networks between different brain regions crucial to learning, memory consolidation, and memory retrieval. Technical advancements in imaging and manipulation approaches have provided deeper understanding of memory formation processes on multi-scales including brain-wide, synaptic, and molecular levels.
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Biological Sciences Department, Brock University; Psychology Department, Brock University. Electronic address:
OTR signaling promotes social approach or facilitates social avoidance, depending on the brain region involved. The lateral septum plays a critical role in regulating social interactions and memory. We investigated the role of OTR signaling in the caudodorsal lateral septum (LSc.
View Article and Find Full Text PDFFood Chem Toxicol
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Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, Heilongjiang 150081, China; Key Lab of Etiology and Epidemiology, Education Bureau of Heilongjiang Province & Ministry of Health (23618504), Harbin Medical University, Harbin 150081, China; Heilongjiang Provincial Key Lab of Trace Elements and Human Health Harbin Medical University, Harbin 150081, China. Electronic address:
Long-term fluoride exposure can produce neurotoxicity. Anthocyanins, as antioxidants, have a certain protective effect in nerve damage. This study aimed to investigate the protective role of anthocyanins in fluoride-induced neurological damage due to endoplasmic reticulum stress (ERS).
View Article and Find Full Text PDFJ Colloid Interface Sci
March 2025
School of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150001, China; Heilongjiang Provincial Key Laboratory of Advanced Quantum Functional Materials and Sensor Devices, Harbin 150001, China. Electronic address:
Optical synaptic devices (OSDs) have neuromorphic vision sensing capability showing great potential in breaking the von Neumann bottleneck and facilitating future artificial vision systems. However, the applications of two-dimensional (2D) material-based OSDs are still impeded by complicated structures, preparation techniques and so on. In this work, we propose a 2D OSD based on BiSe films prepared by a chemical vapor deposition method followed by an in-situ thermal treatment.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
March 2025
Padova Neuroscience Center, University of Padova, Padova 35131, Italy.
Resting brain activity, in the absence of explicit tasks, appears as distributed spatiotemporal patterns that reflect structural connectivity and correlate with behavioral traits. However, its role in shaping behavior remains unclear. Recent evidence shows that resting-state spatial patterns not only align with task-evoked topographies but also encode distinct visual (e.
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