Iliopsoas abscess (IPA) is a rare but potentially life-threatening complication that may occur in patients with Crohn's disease. We present the case of a 28-year-old male with Crohn's disease who developed a complicated IPA. Diagnosis was confirmed via CT imaging and colonoscopy, revealing a fistulous connection to the terminal ileum. The treatment involved percutaneous drainage (PCD), antibiotics, and infliximab. Timely diagnosis, appropriate imaging, and multidisciplinary care are critical to prevent morbidity and recurrence in patients with Crohn's disease complicated by IPA. This case highlights the importance of personalized treatment strategies and close follow-up in managing Crohn's-related IPA.
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http://dx.doi.org/10.1155/carm/5555016 | DOI Listing |
PLoS One
March 2025
Department of Gastroenterology, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Background: Observational studies have shown that ocular manifestations of inflammatory bowel disease (IBD) are common extraintinal manifestations, among which iridocyclitis, scleritis and episcleritis are the most common. However, whether there is a causal relationship between the two is unclear. The purpose of this study was to evaluate the causality of IBD on ocular manifestations using the mendelian randomization (MR) analysis.
View Article and Find Full Text PDFDig Dis Sci
March 2025
Coloproctology Department, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, No. 725 South Wanping Road, Shanghai, 200030, China.
Eur J Nutr
March 2025
Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Biomedical Innovation Center, The Sixth Affiliated Hospital, Key Laboratory of Human Microbiome and Chronic Diseases (Sun Yat-sen University), Guangdong Institute of Gastroenterology, Sun Yat-sen University, Ministry of Education, Guangzhou, 510655, P. R. China.
Purpose: Conflicting results have been reported on dietary factors in inflammatory bowel diseases (IBDs). Here, we compared the dietary intakes of IBD patients with those of paired healthy relatives (HRs), aiming to minimize the impact of genetic and environmental confounders.
Methods: Patients with Crohn's disease (CD, N = 45) and ulcerative colitis (UC, N = 20), their paired HRs (N = 45, N = 20) and healthy non-relative (HNR, N = 25, N = 55) controls were recruited.
Am J Gastroenterol
March 2025
Division of Gastroenterology, Department of Medicine, University of California San Diego, La Jolla, California, USA.
Background And Aims: We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) comparing interleukin (IL)-23p19 antagonists with ustekinumab, stratified by prior biologic exposure, in patients with moderate-to-severe Crohn's disease (CD).
Methods: Through a systematic review through August 17, 2024, we identified phase 2 and 3 RCTs comparing IL-23p19 antagonists vs. ustekinumab in adults with moderate-to-severe CD.
Front Pharmacol
February 2025
Certara Applied BioSimulation, Sheffield, United Kingdom.
Disease activity scores are efficacy endpoints in clinical trials of inflammatory bowel disease (IBD) therapies. Crohn's disease activity index (CDAI), Mayo endoscopic score (MES) and Mayo score are frequently used in clinical trials. They rely on either the physician's observation of the inflammatory state of the patient's gastrointestinal tissue alone or combined with the patient's subjective evaluation of general wellbeing.
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