About 900.000 Forcibly Displaced Myanmar Nationals (FDMN)/ Rohingya refugees live in makeshift camps in Cox's Bazar, Bangladesh. During the COVID-19 pandemic, protective behaviors were particularly important in this setting of previous severe infectious disease outbreaks. To identify barriers, drivers and interventions for those behaviors, a scoping review of MEDLINE, Embase, Web of Science, Global Health and grey literature was conducted in October 2021 and updated in June 2024. The modified Capability-Opportunity-Motivation-Behavior (COM-B) framework and Behavior Change Wheel were used to organize available evidence. A total of 4014 (3654 in 2021, 360 in 2024) records were reviewed and 51 (38 in 2021, 13 in 2024) articles included. Articles reported on protective behaviors (as a general concept), handwashing, social distancing, isolation/quarantine, mask wearing, testing, treatment and vaccination. Barriers and drivers to these behaviors spanned all four COM factors reflecting both individual and environmental influences. Most frequently cited barriers and drivers were found in the motivation (e.g. belief, fear, trust) and physical opportunity (e.g. information, the physical camp environment) factors. Gaps in the evidence were views of health service providers, and differences between camps and population groups. Most interventions focused on information, education or training (e.g. campaigns, community engagement) and environmental restructuring (e.g. increased provision of WASH facilities, COVID-19 isolation and treatment centres). Most articles reported recommendations for interventions. There was some evidence of implementation but little evaluation. This review identified complex and inter-related barriers and drivers to COVID-19 protective behaviors in Cox's Bazar, and many interventions to address these. Addressing the above-mentioned evidence gaps would assist future development of effective targeted interventions, tailored to the needs of specific population groups.
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http://dx.doi.org/10.1016/j.jmh.2024.100295 | DOI Listing |
Front Allergy
February 2025
Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Perth, WA, Australia.
Asthma is a common and complex syndrome, and a major cause of morbidity and healthcare costs. Clinicians have an array of evidence-based investigations and effective interventions at their disposal, but outcomes have not improved as much as trial evidence would suggest they could. This article discusses drivers behind this discrepancy using illustrative examples to highlight information gaps and barriers that impair the delivery of community and emergency asthma care and appropriate referral to specialist asthma services.
View Article and Find Full Text PDFLangmuir
March 2025
Department of Chemical Sciences, Tata Institute of Fundamental Research, Dr. Homi Bhabha Road, Colaba 400005, Mumbai, India.
Despite the widespread use of imidazolium-based ionic liquids (ILs) in biotechnology, pharmaceuticals, and green chemistry, their detailed interactions with proteins, particularly affecting structural stability, remain poorly understood. This study examines the effects of ILs on ubiquitin, a thermodynamically robust protein with a β-grasp structure. We found that IL-induced destabilization follows a consistent order with previous findings: [BMIM] > [BMPyr] > [EMIM] for cations and [BF] > [MeSO] > [Cl] for anions.
View Article and Find Full Text PDFAust J Rural Health
April 2025
Cardiovascular Epidemiology Research Centre, University of Western Australia, Perth, Australia.
Introduction: Preventable rheumatic heart disease (RHD) deaths continue to occur in Australia, with Aboriginal people disproportionately affected. Despite research into structural drivers and the lived experience of people with RHD, and national guidelines focusing on RHD prevention and treatment, recent coronial inquests have highlighted that systemic failures are ongoing. Few studies describe RHD service delivery and/or mortality within the Western Australian (WA) context.
View Article and Find Full Text PDFHealth SA
February 2025
Discipline of Optometry, School of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
Background: Effective implementation of vision screening standards at driving licensing testing centres (DLTCs) necessitates adequate administrative and resource management.
Aim: To ascertain the perspectives of site managers and driver's licence examiners regarding vision screening standards at DLTCs in Gauteng province, South Africa.
Setting: The study was conducted in Gauteng province, South Africa.
Explor Target Antitumor Ther
February 2025
Department of Genetics, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran 16635148, Iran.
Glioblastoma, an aggressive and lethal brain tumor, presents enormous clinical challenges, including molecular heterogeneity, high recurrence rates, resistance to conventional therapies, and limited therapeutic penetration across the blood-brain barrier. The glioblastoma microenvironment, characterized by a dynamic interplay of cellular and non-cellular components, is a key driver of tumor growth and therapeutic resistance. Neuroinflammatory cytokines, particularly interleukins and tumor necrosis factor-alpha, play pivotal roles in this microenvironment, contributing to tumor progression and immune evasion.
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