A two-day workshop activity is described in which postgraduate students are introduced to (i) the theory and application of Design-of-Experiments (DOE) approaches and (ii) the implementation of affordable automation technologies and related data analysis of a system of catalytic interest. This work involved the design and delivery of a short lecture to introduce the theory of DOE followed by practical demonstrations of the application of automation technologies. Specifically, a fractional factorial design was used to interrogate the input space-base, solvent, temperature, time-of the Suzuki-Miyaura cross-coupling (SMCC) of -bromoanisole and -fluorophenylboronic acid using automated solid and liquid handling robots and online HPLC analysis. This was supplemented by a second lecture following data acquisition in which the collected HPLC data was analyzed. The workshop was delivered to a cohort of 15 students at the postgraduate level. Pleasingly, students demonstrated a high degree of engagement with this course structure and reported an increased theoretical understanding of DOE approaches to reaction optimization.
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| http://dx.doi.org/10.1021/acs.jchemed.4c01194 | DOI Listing |
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