Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11831842 | PMC |
| http://dx.doi.org/10.1186/s13054-025-05306-w | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Mass Spectrometric Identification of Urinary Biomarkers of Chronic Kidney Disease: A Proteomic-Related Preliminary Report.
Indian J Nephrol
July 2024
Multi-Disciplinary Centre for Biomedical Research, Aarupadai Veedu Medical College and Hospital, Vinayaka Mission's Research Foundation (Deemed to be University), Kirumampakkam, Puducherry, India.
Background: Chronic kidney disease (CKD) is a gradual loss of kidney function and has an increased prevalence rate worldwide. Our study was intended to identify potential biomarkers of progression using urine proteomics.
Materials And Methods: This preliminary study consisted of 32 patients with stage V CKD.
Leveraging complementary multi-omics data integration methods for mechanistic insights in kidney diseases.
JCI Insight
March 2025
Department of Internal Medicine, Division of Nephrology, University of Michigan, Ann Arbor, Michigan, USA.
Chronic kidney diseases (CKDs) are a global health concern, necessitating a comprehensive understanding of their complex pathophysiology. This study explores the use of 2 complementary multidimensional -omics data integration methods to elucidate mechanisms of CKD progression as a proof of concept. Baseline biosamples from 37 participants with CKD in the Clinical Phenotyping and Resource Biobank Core (C-PROBE) cohort with prospective longitudinal outcome data ascertained over 5 years were used to generate molecular profiles.
View Article and Find Full Text PDFRenalase (RNLS) is a protein playing different roles inside and outside cells. A 20-mer synthetic peptide corresponding to the human RNLS amino acid sequence 220-239 (RP220) exhibits a number of pharmacologically attractive activities in vitro and in vivo and can bind to many renal intracellular proteins. The RP220 sequence contains several cleavage sites for extracellular and circulating proteases.
View Article and Find Full Text PDFThe landscape of renal protein S-acylation in mice with lipid-induced nephrotoxicity.
Sci Rep
March 2025
Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, University of Zurich, Wagistrasse 14, 8952 Schlieren, 8006, Zurich, Switzerland.
Excess fat intake is associated with kidney toxicity and dysfunction. Because fatty acids can also be reversibly attached onto cysteine residues and modulate the function of several membrane-bound proteins, we studied the effect of high-fat diet (HFD) on the S-acylated proteome of mouse kidneys to uncover novel biochemical changes that might contribute to lipid-induced nephrotoxicity. We compared the S-acylated proteome of kidneys from mice fed a chow diet (CD) or a HFD.
View Article and Find Full Text PDFMolecular analysis of acute pyelonephritis-excessive innate and attenuated adaptive immunity.
Life Sci Alliance
March 2025
Division of Microbiology, Immunology and Glycobiology, Department of Laboratory Medicine, Lund University, Lund, Sweden
This study investigated the molecular basis of disease severity in acute pyelonephritis (APN), a common and potentially life-threatening bacterial infection. Two cohorts of infants with febrile urinary tract infection were included. Renal involvement was defined by DMSA scans and molecular disease determinants by gene expression analysis and proteomic screens, at diagnosis and after 6 mo.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!