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Active microgel particle swarms for intrabronchial targeted delivery.
Sci Adv
March 2025
School of Science and Engineering, Chinese University of Hong Kong, Shenzhen, China.
Intrabronchial delivery of therapeutic agents is critical to the treatment of respiratory diseases. Targeted delivery is demanded because of the off-target accumulation of drugs in normal lung tissues caused by inhalation and the limited motion dexterity of clinical bronchoscopes in tortuous bronchial trees. Herein, we developed microrobotic swarms consisting of magnetic hydrogel microparticles to achieve intrabronchial targeted delivery.
View Article and Find Full Text PDFGap-free genome assemblies of two Pyrus bretschneideri cultivars and GWAS analyses identify a CCCH zinc finger protein as a key regulator of stone cell formation in pear fruit.
Plant Commun
March 2025
Institute of Biotechnology, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097, China. Electronic address:
The Chinese white pear (Pyrus bretschneideri) is an economically significant fruit crop worldwide. Previous versions of the P. bretschneideri genome assembly contain numerous gaps and unanchored genetic regions.
View Article and Find Full Text PDFEndothelial Serotonin Receptor 1B Acts as a Mechanosensor to Drive Atherosclerosis.
Circ Res
March 2025
Faculty of Medicine, School of Biomedical Sciences, The Chinese University of Hong Kong (M.J., H.D., C.W.L., Y.X., X.Y., Yu Huang).
Background: Atherosclerosis is characterized by the accumulation of fatty and fibrotic plaques, which preferentially develop at curvatures and branches along the arterial trees that are exposed to disturbed flow. However, the mechanisms by which endothelial cells sense disturbed flow are still unclear.
Methods: The partial carotid ligation mouse model was used to investigate disturbed flow-induced atherogenesis.
Characterization of the complete mitochondrial genome of Wang, Othman, Qiu and Borzée, 2023 (Amphibia, Caudata, Hynobiidae) and its phylogenetic implications.
Mitochondrial DNA B Resour
March 2025
Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystems, College of the Environment and Ecology, Xiamen University, Xiamen, China.
(Caudata, Hynobiidae) is a recently described species, identified in 2022, and is thus not widely known. In this study, we sequenced and annotated the complete mitogenome of . The resulting mitochondrial genome is 16,406 bp in length and comprises 13 protein-coding genes (PCGs), two ribosomal RNA genes (rRNA), 22 transfer RNA genes, and a non-coding region.
View Article and Find Full Text PDFJurassic Park approached: a coccid from Kimmeridgian cheirolepidiacean Aintourine Lebanese amber.
Natl Sci Rev
March 2025
Lebanese University, Faculty of Sciences II, Department of Natural Sciences, Jdeideh, Matn, Lebanon.
With the exception of a fly and a mite from the Triassic of Italy, all Mesozoic amber arthropods are from the Cretaceous. Late Jurassic Lebanese amber from Aintourine revealed a completely preserved adult coccid male (wing length 0.8 mm), gen.
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