Changes in metabolism are associated with several prevalent and rare diseases, like Hunter syndrome (MPS II). These alterations result in changes in mitochondrial function, therefore having non-invasive imaging biomarkers to detect this pathophysiological hallmark is a key objective of translational medicine. Here we report the synthesis and in vivo evaluation of the [F]berberine analogue ([F]BEAN), in both wildtype animals and a mouse model of Hunter's disease. PET/CT imaging revealed that [F]BEAN could detect mitochondrial dysfunction in the heart, liver, and brain of Hunter's disease (Ids KO) mice. These data suggest that [F]BEAN may be a viable translational PET biomarker for the imaging of diverse pathologies that have impaired mitochondrial function.
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| http://dx.doi.org/10.1016/j.bmcl.2025.130142 | DOI Listing |
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