Energised fragments from explosions are the most common wounding mechanism in conflicts and terrorist attacks. Skin covers the vast majority of the human body and is therefore the first anatomical component to be penetrated by fragments, however, its resistance to penetration largely has not been taken into account in models of injury. In this study, an experimental model for ballistic testing of skin is established and a suitable skin simulant for studying resistance to penetration is determined. Fragment-simulating projectiles were fired at human cadaveric skin and skin-simulant candidates. Tissue responses were quantified by evaluating the impact velocity at 50% risk of skin penetration and perforation, and the depth of penetration in cadaveric tissue or skin-simulant candidates. The results identified a 1.5-mm-thick butyl rubber as a suitable skin simulant across the range of threats tested. The findings can help refine assessment of protective systems and predictive models of injury in an effort to improve outcomes of fragment-penetrating injuries.
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http://dx.doi.org/10.1016/j.jmbbm.2025.106936 | DOI Listing |
J Cell Mol Med
March 2025
Hepatobiliary Center, the First Affiliated Hospital of Nanjing Medical University & Research Unit of Liver Transplantation and Transplant Immunology, Chinese Academy of Medical Sciences, Nanjing, Jiangsu, China.
The global incidence of biliary tract cancer (BTC) is on the rise, presenting a substantial healthcare challenge. The integration of immune checkpoint inhibitors (ICIs) with molecularly targeted therapies is emerging as a strategy to enhance immune responses. However, the efficacy and underlying mechanisms of these treatments in BTC are still largely unexplored.
View Article and Find Full Text PDFACS Appl Mater Interfaces
March 2025
State Key Laboratory of Luminescent Materials and Devices, Institute of Polymer Optoelectronic Materials and Devices, Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, South China University of Technology, Guangzhou 510640, P. R. China.
The relationship between the structure and function of condensed matter is complex and changeable, which is especially suitable for combination with machine learning to quickly obtain optimized experimental conditions. However, little research has been done on the effect of temperature on condensed matter and how it affects device performance because the difference between the in situ physical property parameters (which are lowered by the surface tension and mixing entropy) and the basic parameters of the bulk makes accurate AI predictions difficult. In this work, P3HT/ITIC was chosen as the donor/acceptor material for the active layer of organic phototransistors (OPTs).
View Article and Find Full Text PDFACS Nano
March 2025
School of Chemical Science and Engineering, Tongji University, 1239 Siping Road, Shanghai 200092, China.
The self-assemblies of topological complex block copolymers, especially the AB type miktoarm star ones, are fascinating topics in the soft matter field, which represent typical self-assembly behaviors analogous to those of biological membranes. However, their diverse topological asymmetries and versatile spontaneous curvatures result in rather complex phase separations that deviate significantly from the common mechanisms. Thus, numerous trial-and-error experiments with tremendous parameter space and intricate relationships are needed to study their assemblies.
View Article and Find Full Text PDFAnal Chim Acta
May 2025
Department of Human Sciences, The Ohio State University, USA; James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, 43210, USA. Electronic address:
Background: The imperative need for early cancer detection, which is crucial for improved survival rates in many severe cancers such as lung cancer, remains challenging due to the lack of reliable early-diagnosis technologies and robust biomarkers. To address this gap, innovative screening platforms are essential to unveil the chemical signatures of lung cancer and its treatments. It is established that the oxidative tumor environment induces alterations in host metabolic processes and influences endogenous volatile synthesis.
View Article and Find Full Text PDFHandb Clin Neurol
March 2025
Institute of Neurology, Università Cattolica del Sacro Cuore, Fondazione Policlinico A. Gemelli, IRCCS, Rome, Italy. Electronic address:
Since several reviews have recently discussed the lateralization of emotions, this chapter will take into account the possible evolutionary meaning of this lateralization. The organization of the chapter will be based on the following steps. I will first propose that emotions must be considered as a complex adaptive system, complementary to the more phylogenetically advanced cognitive system.
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