In Michel Houellebecq's écriture grise, the decline of Western civilisation is intertwined with contemporary maladies and the fear of ageing. A bleak depiction of ageing bodies functions as an extended metaphor for broader social pathologies, including the decline of spirituality, community well-being, and traditional values. Recurring themes such as the obsession with sex and anti-ageing bodywork, the cult of youth, compulsive consumerism, and erotic hedonism reflect Houellebecq's critique of the transformations of the second half of the 20th century. Many of his protagonists, trapped in an existential midlife crisis and driven by anxieties related to intimate relationships and societal pressures to remain functional, youthful, and engaged, frequently resort to suicide. Using the framework of interdisciplinary age studies and the critical theory of social pathologies, this article discusses how Houellebecq's characters struggle to navigate the challenges within competitive neoliberal imperatives, libidinal economies, and the discourse of successful ageing. It also underscores how his oeuvre, often characterised as apocalyptic, dystopian, or neo-decadent, advocates for authentic connection, care, faith, and unconditional love as essential components of human existence and survival.
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http://dx.doi.org/10.1093/geront/gnaf069 | DOI Listing |
Handb Clin Neurol
March 2025
University School for Advanced Studies (IUSS-Pavia), Pavia, Italy; Dementia Research Center, IRCCS Mondino Foundation, Pavia, Italy. Electronic address:
Hemispheric asymmetry in pathologic involvement is frequently observed in neurodegenerative disorders (NDD) and is responsible for differences in cognitive and motor clinical manifestations in individual patients. While asymmetry is modest in typical Alzheimer disease (AD), atypical AD presentations with prominent language impairment [logopenic/phonologic variant of primary progressive aphasia (L/Phv-PPA)] are associated with prevalent involvement of the language-dominant hemisphere. Similarly, in the frontotemporal dementia-amyotrophic lateral sclerosis (FTD-ALS) spectrum, the semantic (Sv) and nonfluent/agrammatic (Nf/Av) variants of PPA are due to asymmetric pathology involving the language-dominant hemisphere.
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March 2025
Division of Social Pharmacy, Center for Social Pharmacy and Pharmaceutical Care Sciences, Faculty of Pharmacy, Keio University, Tokyo, Japan.
Undernutrition is a common risk after surgery or during periods when oral dietary intake is challenging. Enteral nutrients, frequently utilized in nutritional management, are drugs associated with multiple contraindications involving pathology and allergy, and they require careful attention in dispensing. However, the occurrence of nutrition-related incidents in community pharmacies remains unknown.
View Article and Find Full Text PDFSci Adv
March 2025
Functional Neuroimaging Laboratory, Istituto Italiano di Tecnologia, Center for Neuroscience and Cognitive Systems @UniTn, Rovereto, Italy.
Chromosome 22q11.2 deletion increases the risk of neuropsychiatric disorders like autism and schizophrenia. Disruption of large-scale functional connectivity in 22q11 deletion syndrome (22q11DS) has been widely reported, but the biological factors driving these changes remain unclear.
View Article and Find Full Text PDFAddict Biol
March 2025
Departament de Psicologia Bàsica, Clínica i Psicobiologia, Universitat Jaume I, Castellón, Spain.
Repetitive drug use results in enduring structural and functional changes in the brain. Addiction research has consistently revealed significant modifications in key brain networks related to reward, habit, salience, executive function, memory and self-regulation. Techniques like Voxel-based Morphometry have highlighted large-scale structural differences in grey matter across distinct groups.
View Article and Find Full Text PDFCells
February 2025
Department of Anesthesiology, University of California, San Diego, CA 92093, USA.
A significant portion of adolescents suffer from mental illnesses and persistent pain due to repeated stress. The components of the nervous system that link stress and pain in early life remain unclear. Prior studies in adult mice implicated the innate immune system, specifically Toll-like receptors (TLRs), as critical for inducing long-term anxiety and pain-like behaviors in social defeat stress (SDS) models.
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