The skin is a large and sophisticated organ populated by innate and adaptive immune effector cells. These immune cells provide a critical first line of defense against pathogens, but genetic and environmental factors can lead to inappropriate signaling that may manifest as hypersensitivity. The most common cutaneous allergic disorders in children include atopic dermatitis, urticaria/angioedema, and contact dermatitis. In this review, we will briefly review these conditions, with a focus on recent developments in our understanding of the diagnosis and management of these disorders.
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http://dx.doi.org/10.1111/pai.70038 | DOI Listing |
Exp Dermatol
March 2025
Juntendo Itch Research Center (JIRC), Institute for Environmental and Gender-Specific Medicine, Juntendo University Graduate School of Medicine, Chiba, Japan.
Ceramides in the stratum corneum (SC) are important for epidermal barrier function. We previously developed a synthetic pseudo-ceramide for medical (SPCM)-containing steroid cream [SPCM (+)]. This cream forms films on the skin surface and exerts anti-inflammatory effects through steroids.
View Article and Find Full Text PDFIndian J Otolaryngol Head Neck Surg
February 2025
Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh India.
Osteosarcoma, although the most common malignant bone tumor in long bones, represents only 5-8% of head and neck tumors, making it uncommon for clinicians. Conventional biopsy techniques can complicate diagnosis due to varying tissue representation in surrounding areas. This article discusses a case involving a 19-year-old female who presented with facial swelling and a rapidly growing intraoral mass.
View Article and Find Full Text PDFAllergic contact dermatitis (ACD) is an inflammatory dermatitis with a high morbidity and recurrence rate. Scientific attention is focused on the development of safe and comfortable therapeutics of ACD. Herein, we propose a natural matrine-integrated pollen delivery system for the ACD treatment.
View Article and Find Full Text PDFSci Rep
March 2025
Department of Polymer Chemistry, Faculty of Chemistry, University of Isfahan, Isfahan, 81746-73441, Iran.
This study developed a self-healing, anti-corrosive coating based on a novel nanocomposite formulation of 8-hydroxyquinoline-5-sulfonic acid-zinc doped polyaniline (HQZn-PA) incorporated into an epoxy matrix. The chemical composition and surface morphology of the synthesized nanocomposite were thoroughly characterized using Fourier transform infrared spectroscopy, X-ray diffraction, nuclear magnetic resonance, and scanning electron microscopy. Electrochemical impedance spectroscopy and potentiodynamic polarization tests confirmed the outstanding corrosion resistance and self-healing efficiency of the coating.
View Article and Find Full Text PDFInt J Biol Macromol
March 2025
Centre of Excellence in Biomaterials and Tissue Engineering, Materials Science Engineering Department, Government College University, Lahore, Pakistan. Electronic address:
The fast degradation rate of implants of AZ 31 alloy in the physiological body fluid is a critical problem for orthopaedic applications. The surface modification of AZ 31 can regulate fast degradation by depositing a biocompatible composite coating. Herein, chitosan/ iron-doped bioactive glass (Fe-doped BG) particles were deposited on AZ 31 via electrophoretic deposition (EPD) at optimized parameters (electric field 15 V/cm with 5 min as deposition time).
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