Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/postmj/qgaf023 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
NTRK protein expression in NSCLC and its clinicopathological correlation.
Histol Histopathol
February 2025
Department of Clinical Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden.
Non-small cell lung cancer (NSCLC) is a complex disease with diverse clinical and molecular characteristics. Since the discovery of the oncogenic neurotrophic receptor tyrosine kinase (NTRK) gene fusion in colorectal cancer in 1986, its understanding has gradually progressed. NTRK's relevance is crucial to understanding some tumor development and how specific tyrosine receptor kinase inhibitors (TRKI) work.
View Article and Find Full Text PDFTransforming Trans-nasal Endoscopy Services: A multicentre service evaluation pilot project.
Clin Med (Lond)
March 2025
Barking, Havering and Redbridge NHS Foundation Trust.
Objectives: To assess the impact of pilot Transnasal endoscopy (TNE) services on workforce efficiency, allocated procedure times and patient tolerance of procedures. The aim was to also understand the challenges of setting up a TNE service.
Methods: Six-month data was collected from ten sites.
Intracellular and extracellular activities of V-domain Ig-containing suppressor of T cell activation (VISTA) modulated by immunosuppressive factors of tumour microenvironment.
Cancer Lett
February 2025
Medway School of Pharmacy, Universities of Kent and Greenwich, Chatham Maritime, UK. Electronic address:
V-domain Ig-containing suppressor of T cell activation (VISTA) is a unique immune checkpoint protein, which was reported to display both receptor and ligand activities. However, the mechanisms of regulation of VISTA activity and functions by factors of tumour microenvironment (TME) remain unclear and understanding these processes is required in order to develop successful personalised cancer immunotherapeutic strategies and approaches. Here we report for the very first time that VISTA interacts with another immune checkpoint protein galectin-9 inside the cell most likely facilitating its interaction with TGF-β-activated kinase 1 (TAK1).
View Article and Find Full Text PDFTransforming the NHS through AI-driven solutions: a new era of digital health.
Postgrad Med J
February 2025
Department of Infection, Centre for Clinical Microbiology, Division of Infection and Immunity, University College London, Gower St, London, WC1E 6BT, United Kingdom.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!