Background: Although recent animal experiments have revealed that tea intake improves elevated serum uric acid (SUA) levels, a causal link between the consumption of different types of tea and SUA levels remains undetermined.
Methods: Bidirectional Mendelian randomization (MR) analysis based on genome-wide association studies was used to assess the causal relationship between consumption of different types of tea and the risk of elevated SUA levels in European and Asian populations.
Results: Forward MR analysis showed that tea intake was significantly associated with lower SUA levels (p = 0.0013). The estimated effect value ( -0.0440) suggests that for every 1-unit increase in tea intake, there is a 0.044-unit decrease in SUA levels. However, there is no reverse causality between SUA and tea intake (p = 0.2824). No causal relationship was found between the consumption of different types of tea and risk of elevated SUA levels (p > 0.05).
Conclusion: Although this bidirectional MR study provided evidence of a causal relationship between tea intake and SUA levels, however, due to limitations associated with the sample size and strength of instrumental variables, a definite conclusion was not possible.
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| http://dx.doi.org/10.1111/1756-185X.70128 | DOI Listing |
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