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Differential interference contrast (DIC) imaging is essential in both biological research and medical diagnostics. Despite considerable progress in theoretical and experimental frameworks, limited by the inefficient cameras, achieving direct DIC imaging with infrared (IR) illumination remains a formidable challenge. However, infrared DIC imaging is urgent for diverse fields. Here, we creatively leverage the walk-off effect, a limitation in nonlinear optics, to solve this obstacle and present the nonlinear DIC imaging. The critical component of our scheme is a nonlinear beam displacer (NBD) made up of two quadrature-cascaded type I nonlinear crystals. When the infrared beam carrying object information passes through the proposed NBD, it undergoes nonlinear coupling with the pump beam and then generates two orthogonally polarized visible beams with a slight spatial displacement dominated by the walk-off effect. Accordingly, by selecting polarization, the lateral shear interference for realizing DIC imaging can be realized, and thus the phase discontinuities of the object can be visualized with infrared illumination. Our finding brings DIC imaging technology into the realm of upconversion infrared imaging, paving the way for infrared phase microscopy imaging.
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http://dx.doi.org/10.1364/OL.544874 | DOI Listing |
Drugs Context
March 2025
Department of Psychiatry, Creighton University School of Medicine, Omaha, NE, USA.
This Editorial reviews data on the efficacy and adverse effects of lecanemab amongst individuals with mild Alzheimer disease. Additionally, the recent controversy regarding the rejection by the EMA of a marketing authorization request for lecanemab, followed by its subsequent approval, is also discussed. The need for thoughtful discussions regarding the risks and benefits of this medication as well as the importance of developing Appropriate Use Recommendations and/or national guidelines for the use of lecanemab are also highlighted.
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March 2025
Construction Engineering Research Laboratory (CERL), Engineer Research and Development Center (ERDC), United States Army Corps of Engineers (USACE), Champaign, IL 61826, USA.
Navigable waterways play a vital role in the efficient transportation of millions of tons of cargo annually. Inland traffic must pass through a lock, which consists of miter gates. Failures and closures of these gates can significantly disrupt waterborne commerce.
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February 2025
School of Resources and Safety Engineering, Central South University, Changsha 410083, China.
Jointed soft-hard composite rocks are frequently encountered in nature, and this complex structure contributes to unpredictable fracturing mechanisms and failure behavior. In this study, soft-hard composite rocks with three joints were fabricated to conduct a uniaxial loading experiment, supplemented by Digital Image Correlation (DIC) and Acoustic Emission (AE) experiments. The results indicate that the mechanical parameters display a V-shape variation trend with the increase of joint angle, which minimized at 30°.
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February 2025
The Faculty of Mechanical Engineering, Wrocław University of Science and Technology, Łukasiewicza 5 St., 50-370 Wroclaw, Poland.
The study investigates the mechanical characterization of PET-G components fabricated via Fused Deposition Modeling (FDM), integrating experimental testing with advanced numerical modeling. Initially, an extensive parametric analysis was conducted to determine the optimal printing conditions, focusing on temperature, speed, and infill density to ensure reliable and repeatable sample fabrication. Subsequently, the study employs an inverse problem-solving approach that combines Digital Image Correlation (DIC) with Finite Element Method Updating (FEMU) to identify the material parameters, specifically Young's modulus and Poisson's ratio.
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February 2025
School of Civil Engineering, Yancheng Institute of Technology, Yancheng 224051, China.
This study investigates the mechanical properties and microstructure of basalt fiber (BF) and nanoalumina (NA)-modified ultra-high-performance concrete with recycled aggregates (UHPC-RA) under high-temperature conditions. The effects of different replacement rates of recycled aggregates (RAs), BF content, and NA content on the compressive strength, splitting tensile strength, and elastic modulus were evaluated at ambient temperatures and after exposure to 200 °C, 400 °C, 600 °C, and 800 °C. The results show that mechanical properties decrease with temperature rise, but specimens containing BF exhibited improved crack resistance and better high-temperature integrity.
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