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The Province of British Columbia (BC) is in the midst of an ongoing public health emergency, declared in 2016 in response to significant levels of drug poisonings/overdoses stemming from the unregulated drug supply. In response, BC implemented decriminalization in 2023, removing criminal sanctions for adults possessing up to 2.5 cumulative grams of opioids, cocaine, methamphetamine, and MDMA.

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Pridopidine in Amyotrophic Lateral Sclerosis: The HEALEY ALS Platform Trial.

JAMA

February 2025

Sean M. Healey and AMG Center for ALS and the Neurological Clinical Research Institute, Massachusetts General Hospital, Harvard Medical School, Boston.

Importance: Amyotrophic lateral sclerosis (ALS) is a fatal disease. The sigma-1 (σ1) receptor emerged as a target for intervention.

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Purpose Of Review: In the alcohol research literature, many studies demonstrate the impact of advertisements, outlet density, and perceived norms on attitudes and behaviors. Now that Washington State has exceeded 11 years of legal cannabis for non-medical purposes, building upon the existing evidence base with alcohol, we can examine what contributes to perceived harm and availability with cannabis in a legal context and begin to explore opportunities for future research.

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Hyperbaric oxygen therapy (HBOT) is an established treatment for acute acoustic trauma (AAT), with early intervention believed to improve hearing recovery. Evidence suggests that initiating HBOT within seven days of AAT onset results in superior hearing outcomes compared to later treatment. Linear regression models have estimated hearing improvements of approximately 24% and 14% for early (≤ 7 days) and late (> 7 days) treatment groups, respectively.

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Geometry as a Guide: Enclosure Effects on Spatial Mapping (Commentary on Xu et al. 2024).

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Fac. Cs. Exactas-INTIA, Universidad Nacional del Centro de la Provincia de Buenos Aires (UNCPBA), Tandil, Buenos Aires, Argentina.

A recent paper by Xu et al. proposes that cognitive maps in mice emerge during spatial navigation from path integration anchored to a starting position. We challenge this understanding by arguing that enclosure geometry rather than path integration shapes cognitive maps.

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