Although the World Health Organization recommends 2 tetanus vaccine-containing injections in pregnancy, in Uganda, only 59.2% of pregnant women received a 2nd dose in 2022. We set out to (1) create awareness of maternal vaccine-preventable diseases, maternal immunization benefits and vaccination safety through the use of media; (2) determine the effectiveness of maternal immunization campaigns and (3) assess stakeholder's acceptability of project interventions' delivery methods.
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http://dx.doi.org/10.1097/INF.0000000000004635 | DOI Listing |
J Infect
March 2025
Department of Infectious Diseases, Perth Children's Hospital, Perth, Western Australia, Australia; Wesfarmers Centre for Vaccines and Infectious Diseases, The Kids Research Institute Australia, University of Western Australia, Perth, Western Australia, Australia; School of Medicine, University of Western Australia, Perth, WA, Australia; Department of Microbiology, PathWest Laboratory Medicine, Perth, Western Australia, Australia.
Background: Respiratory Syncytial Virus (RSV) causes a significant burden of illness for children under 2 years of age. Nirsevimab, a long-acting monoclonal antibody, was registered for RSV prevention in Australia in 2023. In April 2024, Western Australia (WA) launched the country's first state-wide nirsevimab program for all infants and high-risk children entering their second RSV season.
View Article and Find Full Text PDFAm J Obstet Gynecol
March 2025
Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore; National Centre for Infectious Diseases, Singapore; Duke-NUS Graduate Medical School, National University of Singapore, Singapore; Department of Infectious Diseases, Singapore General Hospital, Singapore. Electronic address:
Background: Significant heterogeneity has been reported in estimates of long-term sequelae following SARS-CoV-2 infection in pregnant women, and most studies were conducted pre-Omicron and pre-dated vaccination rollout. Less severe COVID-19 attributed to milder Omicron may potentially attenuate risk of post-COVID-19 sequelae.
Objective: We sought to examine long-term risk of new-incident multi-systemic sequelae following SARS-CoV-2 Delta/Omicron infection in a population-based cohort of pregnant women, contrasted against a)test-negatives; b)infected non-pregnant women of childbearing age.
Ecotoxicol Environ Saf
March 2025
Department of Gynecology and Obstetrics, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, School of Clinical Medicine of Henan University, Zhengzhou, Henan 450003, China. Electronic address:
Maternal exposure to polystyrene nanoplastics (PS-NPs) during pregnancy and lactation has been linked to adverse effects on offspring kidney development, with sex-specific outcomes. This study investigated the impact of maternal PS-NPs exposure on kidney weight, histology, transcriptomics, and functional pathways in offspring mice. Offspring exposed to PS-NPs exhibited significantly lower body weight (P < 0.
View Article and Find Full Text PDFJ Infect Public Health
March 2025
Department of Obstetrics and Gynecology, Women and Children's Hospital of Chongqing Medical University, Chongqing 401147, China; Department of Pharmacology, Academician Workstation, Changsha Medical University, Changsha 410219, China. Electronic address:
Background: Despite evidence showing changes in disease severity with the virus's evolution and vaccination efforts, the link between maternal, perinatal, and neonatal outcomes and SARS-CoV-2 infections during different pregnancy trimesters remains unclear, especially with the BA.5 and BF.7 Omicron subvariant surge in China in December 2022.
View Article and Find Full Text PDFFront Immunol
March 2025
Department of Clinical Laboratory, Guangxi Medical University Cancer Hospital, Nanning, China.
Background: nuclear-associated antigen Ki67 (Ki67) emerges as a clinically practical biomarker for proliferation assessment among many cancer types. However, the definite prognostic value of Ki67 against a specific cancer type has remained vague. This study aims to perform a comprehensive pan-cancer analysis of the prognosis value of Ki67 across various cancer types.
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