An intermolecular coupling between sulfoximines and allyl amines, linked to the picolinamide directing group, is developed by leveraging a nucleopalladation-guided regioselective hydroamination strategy, enabling the production of a range of valuable -alkyl sulfoximines in high yields. The protocol features operational simplicity and a broad substrate scope and was also amenable to aniline nucleophiles. Synthetic utilities were showcased through scale-up reactions and product diversifications, leading to biorelevant molecules.
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