Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/imm.13904 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Microbiological aetiology of paediatric respiratory tract infections in Kyrgyzstan.
BMC Infect Dis
February 2025
Department of Clinical Microbiology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Introduction: Respiratory tract infections (RTIs) are a leading cause of morbidity and mortality in children worldwide. Aetiologic virus and bacteria vary geographically. To date, no systematic data on RTI aetiologies have been published from Kyrgyzstan, a country with a high under-five mortality from lower RTIs and a widespread overuse of antibiotics.
View Article and Find Full Text PDFPrevalence study of antimicrobial resistant organisms in very preterm neonates.
Ir J Med Sci
February 2025
Department of Clinical Microbiology, National Maternity Hospital, Holles Street, Dublin, D02YH21, Ireland.
Background: Preterm neonates have underdeveloped organs, a fragile skin barrier and an immature immune system rendering them susceptible to infection. These infants are at an increased risk of developing a healthcare-associated infection because of antibiotic exposure, invasive monitoring and the general risk of outbreaks within a hospital setting. The aim of this study was to investigate the prevalence of antimicrobial resistant organism carriage in very preterm neonates (i.
View Article and Find Full Text PDFControlled human infection model of Neisseria lactamica in late pregnancy investigating mother-to-infant transmission in the UK: a single-arm pilot trial.
Lancet Microbe
February 2025
Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK; NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Background: The infant respiratory microbiome is derived largely from the mother and is associated with downstream health and disease. Manipulating maternal respiratory flora peripartum to influence the infant microbiome has not previously been investigated. Neisseria lactamica is a harmless pharyngeal commensal that correlates inversely with Neisseria meningitidis carriage and disease.
View Article and Find Full Text PDFMaternal Carriage of Prevotella copri Is Associated With Increased Thymus Derived Naïve Regulatory T Cells in Cord Blood.
Immunology
April 2025
Institute for Physical and Mental Health and Clinical Transformation, Deakin University, Melbourne, Australia.
Genetically edited human placental organoids cast new light on the role of ACE2.
Cell Death Dis
February 2025
Flinders University, College of Medicine and Public Health, Flinders Health and Medical Research Institute, Adelaide, SA, Australia.
ACE2 expression is altered in pregnancy disorders and ACE2 gene variants are associated with several major pregnancy complications including small-for-gestational-age, fetal growth restriction and preeclampsia. This study utilised gene-editing to generate both ACE2 knockout and ACE2 rs2074192 placental organoids, facilitating mechanistic studies into the role of ACE2 in placental development, and the effect of fetal carriage of ACE2 rs2074192 CC, CT and TT genotypes. Parameters of cell and organoid growth were measured, together with qPCR, Western Blotting, and ELISA assessments, in all groups from both organoid models.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!