Gan To Kagaku Ryoho
Dept. of Surgery Chubu Tokushukai Hospital.
Published: December 2024
39-year-old woman with no significant medical history was found to have a pancreatic body tumor during abdominal ultrasound screening at our hospital. The ultrasound revealed a hypoechoic tumor with internal calcifications measuring 29×17 mm, displaying minimal internal vascularity. A contrast-enhanced CT scan characterized the lesion as a poorly enhancing solid tumor. Based on these findings, a suspicion of solid pseudopapillary neoplasm(SPN)of the pancreas was primary, leading to a laparoscopic spleen-preserving distal pancreatectomy. Pathologically, the tumor exhibited areas of solid and hemorrhagic necrosis, with irregularly interspersed hyaline stroma. Immunohistochemical staining showed diffuse positivity for vimentin, nuclear and cytoplasmic positivity for β-catenin, partial positivity for synaptophysin and CD10, and negativity for chromogranin A, bcl 10, and trypsin, confirming the diagnosis of SPN. This case report details the suspicion and successful laparoscopic surgical management of pancreatic SPN in a young female, reflecting on the radiological features and providing some brief literature review.
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Iran J Pathol
January 2025
Department of Biostatistics, Shiraz University of Medical Sciences, Shiraz, Iran.
Background & Objective: Limited literature describes the accuracy of endoscopic ultrasonography-fine needle aspiration (EUS-FNA) cytology in various types of pancreatic epithelial tumors, and this underscores the usefulness of cell blocks, and highlights potential diagnostic pitfalls.
Methods: This study included 108 patients who underwent EUS-FNA pancreatobiliary cytology followed by surgery. Age, gender, tumor location, tumor size, presence or absence of a cell block, cytologic and pathologic diagnoses, and histologic tumor grade were recorded.
Zhonghua Wai Ke Za Zhi
March 2025
Department of General Surgery, the Children's Hospital Affliated to Xiangya School of Medicine(Hunan Children's Hospital), Central South University, Changsha 410000, China.
To summarize the clinical traits, diagnostic and therapeutic experiences of pancreatic tumors in children. This is a retrospective case series study. According to inclusion and exclusion criteria, clinical data of 35 children with primary pancreatic tumors who were treated at the Department of General Surgery, the Children's Hospital Affiliated to Xiangya School of Medicine, Central South University were collected from January 2010 to June 2023.
View Article and Find Full Text PDFNPJ Precis Oncol
March 2025
Department of Medical Oncology, BC Cancer, Vancouver, BC, Canada.
Pancreatic solid pseudopapillary neoplasms (SPNs) are uncommon tumors that rarely exhibit aggressive behavior. Given disease rarity, comprehensive studies to understand tumor biology, clinical course, and optimal management are limited. We describe an unusual case of a 55-year-old man with metastatic pancreatic SPN, where whole-genome and transcriptome analyses of the primary tumor and a metastatic liver lesion revealed a shared homozygous non-canonical mutation in APC.
View Article and Find Full Text PDFJ Hepatobiliary Pancreat Sci
February 2025
Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin's Clinical Research Center for Cancer, Tianjin, China.
Background: Nuclear expression of CTNNB1 is occasionally negative in solid-pseudopapillary neoplasm (SPN) of the pancreas, leading to a missed diagnosis. In the present study, we aimed to investigate the clinical significance of CTNNB1 mutation detection for diagnosing SPN and explore the difference in clinicopathological characteristics at different ages and sex.
Methods: Patients who underwent surgery for a pathologically confirmed SPN in our institution between 2011 and 2020 were collected.
39-year-old woman with no significant medical history was found to have a pancreatic body tumor during abdominal ultrasound screening at our hospital. The ultrasound revealed a hypoechoic tumor with internal calcifications measuring 29×17 mm, displaying minimal internal vascularity. A contrast-enhanced CT scan characterized the lesion as a poorly enhancing solid tumor.
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