Severity: Warning
Message: file_get_contents(https://...@pubfacts.com&api_key=b8daa3ad693db53b1410957c26c9a51b4908&a=1): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
Filename: helpers/my_audit_helper.php
Line Number: 197
Backtrace:
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 197
Function: file_get_contents
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 271
Function: simplexml_load_file_from_url
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 1057
Function: getPubMedXML
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3175
Function: GetPubMedArticleOutput_2016
File: /var/www/html/application/controllers/Detail.php
Line: 575
Function: pubMedSearch_Global
File: /var/www/html/application/controllers/Detail.php
Line: 489
Function: pubMedGetRelatedKeyword
File: /var/www/html/index.php
Line: 316
Function: require_once
J Pak Med Assoc
5th Year MBBS Student, Federal Medical College, Pakistan Institute of Medical Sciences, Islamabad, Pakistan.
Published: February 2025
Immune Thrombocytopenia Purpura (ITP) is an autoimmune disorder characterised by a low blood platelet count, which is attributed to both decreased megakaryocyte production in the bone marrow and the generation of autoantibodies causing platelet destruction in the spleen. Individuals with autoimmune conditions are highly susceptible to pulmonary embolism. This case involves a 39-year-old female with ITP who developed thromboembolisms. A comprehensive investigation into prothrombotic risk factors, including obesity, smoking, family history of thromboembolism, and ITP-related interventions such as prolonged corticosteroid use or splenectomy, revealed insignificant results, except for the patient's history of receiving corticosteroid therapy. Despite the disparate pathogenesis of thromboembolism (TE) and ITP, recent events of TE in ITP patients have been observed. This report underscores the potential lifethreatening complications in ITP and aims to explore their causes and pathogenesis for ensuring optimised patient care.
Download full-text PDF |
Source |
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http://dx.doi.org/10.47391/JPMA.10689 | DOI Listing |
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