Ann Surg Oncol
Department of Gastroenterology and Hepatology, Isala, Zwolle, The Netherlands.
Published: February 2025
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http://dx.doi.org/10.1245/s10434-025-16997-4 | DOI Listing |
Ann Surg Oncol
March 2025
Department of Surgery, St. Paul's Hospital, University of British Columbia, Vancouver, BC, Canada.
Ann Surg Oncol
March 2025
Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Ann Surg Oncol
March 2025
Section of Colon and Rectal Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA.
Int J Mol Sci
March 2025
The Department of Molecular Biology, Cell Biology & Biochemistry, Brown University, Providence, RI 02903, USA.
The ubiquitin-protein ligase E3A (UBE3A, aka E6-AP), an E3 ligase belonging to the HECT family, plays crucial roles in the stability of various proteins through the proteasomal degradation system. Abnormal UBE3A activity is essential for the initiation and progression of several cancers. A gain of function and an overdosage of maternal UBE3A is associated with an increased risk of autism spectrum disorders.
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