Reading relies on the incremental processes that occur across all words in a passage to build a global comprehension of the text. Factorial experimental designs are not well-suited to examine these incremental processes, which are influenced by multilevel factors in an overlapping manner. Exemplifying an alternative approach, we combined event-related potentials, probabilistic language models, authentic texts, and statistical methods to examine the time course of multilevel linguistic influences on the incremental processes which occur during reading each word. We found that indicators of the initial stages of word identification (N170 and P200) are sensitive to context-independent statistical information of a word, for example, word frequency. The later stages of word processing, involving processes related to meaning retrieval and integration (N400), heavily rely on the word's context-dependent information measured by word surprisal. Syntactic processing, reflected by a word's syntactic surprisal and the number of phrase structures it closes, was presented across multiple phases (an early negativity, N400, and a late positivity). Additionally, the effects of position factors at both the word and sentence levels emerged across multiple time windows (including N170, P200, and N400), suggesting their distinct influence beyond linguistic factors. These findings provide a theoretically coherent picture of incremental reading, partly convergent with conclusions from factorial studies but with novel results concerning the time courses and interactions of processing components. (PsycInfo Database Record (c) 2025 APA, all rights reserved).
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http://dx.doi.org/10.1037/xlm0001438 | DOI Listing |
Pharmaceut Med
March 2025
The Academy of Global Medicines Development Professionals (GMDP Academy), New York, NY, USA.
Medicines development has dramatically transformed in the preceding decades. It has evolved from a task undertaken by a small team to a complex series of activities, involving several functions and qualified professionals, across multiple, interrelated, scientific disciplines, worldwide. Conceptualized as a medical specialty, concerned with the research, development, and monitoring of medicines, and spearheaded largely by pharmaceutical physicians, the discipline has extended to embrace non-medically qualified scientists progressively taking on traditional roles within the medicines development ambit.
View Article and Find Full Text PDFInt J Womens Health
March 2025
Center of Excellence for Pharmaceutical Care Innovation, Universitas Padjadjaran, Bandung, Indonesia.
Introduction: Multiple micronutrient deficiencies might increase the adverse outcome during pregnancy and after birth. Considering the WHO recommendations since 2016 and scientific evidence from previous studies that multiple-micronutrient supplementation (MMS) is more effective than iron folic acid (IFA) in improving pregnant women's health, it is imperative to conduct an economic evaluation to assess the cost-effectiveness of MMS compared with IFA.
Methods: We conducted a systematic review from PubMed and Scopus to identify the cost-effectiveness analyses of MMS compared to IFA for pregnant women up to January 2024.
Front Pharmacol
February 2025
Department of Endocrinology and Metabolism, MAGIC China Center, West China Hospital of Sichuan University, Chengdu, China.
Objective: Sodium-glucose cotransporter-2 (SGLT2) inhibitors showed time-varying effects in heart failure and reduced ejection fraction (HFrEF), but corresponding cost-effectiveness in different timeframes remained poorly understood. This study estimated the time-varying cost-effectiveness of SGLT2 inhibitors in HFrEF from the perspective of the Chinese healthcare system.
Methods: Based on real-world individual patient data, a 2-year microsimulation model was constructed to evaluate the cost-effectiveness of adding SGLT2 inhibitors to standard therapy compared with standard therapy alone among patients with HFrEF.
BMC Med
March 2025
Health Economics and Policy Evaluation Research (HEPER) Group, Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Melbourne, Australia.
Background: Long-term cost-effectiveness analyses of health behaviour interventions to effectively manage type 2 diabetes mellitus (T2DM) in low-income countries are crucial for minimising economic burden and optimising resource allocation. Therefore, this study aimed to estimate the long-term cost-effectiveness of implementing a health behaviour intervention to manage T2DM in Nepal.
Methods: A Markov model in combination with a decision tree was developed to compare the costs and outcomes of the health behaviour intervention against usual care among 481 (238-intervention and 243-control) participants from healthcare system and societal perspectives.
Inflamm Bowel Dis
March 2025
Max-Planck-Institut für die Physik des Lichts, Erlangen, Germany.
Background: Inflammatory bowel disease (IBD) is one of the fastest-growing diseases globally. Nearly 5 million people are affected by IBD, with an incremental growth rate of 47.45% between 1990 and 2019.
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