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Efficacy and safety of mesenchymal stem cell therapies in retinitis pigmentosa: a systematic review and meta-analysis.
Int Ophthalmol
March 2025
Burapha University Hospital, Burapha University, Saen Suk, Chonburi, Thailand.
Background: Retinitis pigmentosa (RP) is a retinal dystrophy and genetically heterogeneous group that causes vision loss and necessitates innovative therapeutic strategies, and mesenchymal stem cell (MSC) therapy has shown potential due to its regenerative and immunomodulatory properties. This meta-analysis aims to evaluate the efficacy and safety of MSC therapies in improving visual outcomes, focusing on the impact of various MSC types, administration methods, and duration of benefits.
Methods: A systematic search of peer-reviewed studies was conducted to identify clinical trials and observational studies investigating MSC therapies for retinal conditions.
Dengue in patients with kidney transplant: a systematic review.
Infez Med
March 2025
Masters' Program of Clinical Epidemiology and Biostatistics, Faculty of Health Sciences, Universidad Cientifica del Sur, Lima, 15067, Peru.
Introduction: The incidence of dengue and its complications increases globally, mainly in areas where it is endemic; however, little literature evaluates outcomes in kidney transplant recipients (KTR). The present analysis aimed to determine the incidence, signs and symptoms, and allograft dysfunction in dengue-infected KTR.
Methods: Systematic review of the literature following PRISMA 2020 indications with studies included until November 24, 2023.
Longitudinal clinical characteristics of patients with neurofibromatosis type 1.
Can J Ophthalmol
March 2025
Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria. Electronic address:
Purpose: This study reports on longitudinal clinical characteristics of patients with neurofibromatosis type 1 (NF1) treated at the Department of Ophthalmology of the Medical University of Vienna.
Methods: This retrospective study included children with a genetically proven diagnosis of NF1. Clinical characteristics and outcomes, including best-corrected visual acuity (BCVA), refractive error, ocular motility, specific ophthalmological findings (e.
Astrocyte activation in the cat dLGN following monocular retinal inactivation.
Vision Res
March 2025
Department of Psychology & Neuroscience, Dalhousie University, Halifax, NS B3H 4R2, Canada.
Monocular deprivation obstructs the development of visual neural circuits and can impair vision for a lifetime. Effective treatment of this visual disorder, amblyopia, with patching therapy is limited by a short and early critical period, as well as by poor compliance with prescribed treatment. Temporary pharmacological inactivation of the dominant eye has emerged as a means to rapidly correct the effects of monocular deprivation in animal models.
View Article and Find Full Text PDFLow Vision Services Are Underutilized by Patients with Vision Loss from Corneal Disease.
Cornea
March 2025
Division of Ophthalmology, Department of Surgery, UMass Chan - Lahey School of Medicine, Burlington, MA.
Purpose: This study evaluated the rate at which patients with visual impairment primarily from corneal disease were referred for low vision (LV) services and assessed the visual outcomes from completed evaluations.
Methods: This 1-year retrospective, cross-sectional study included patients with corneal disease limiting best-corrected visual acuity (BCVA) to ≤ 20/40. Outcome measures included the change in BCVA achieved after distance refraction by a LV specialist.
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