Peripheral nerve field stimulation (PNFS) can effectively manage pain localized to one or two dermatomes that are refractory to conventional approaches, such as chronic low back pain. However, its utility in pain management in the upper limbs is limited due to the risk of lead displacement related to articular and mobile segment constraints.In this technical note, we describe a 58-year-old man with neuropathic pain refractory to extensive medical treatment, and dorsal root entry zone lesion. Considering the patient's favorable response to transcutaneous electrical nerve stimulation, we used a two-step lead placement approach to improve the permanent placement of the electrode leads in the upper limb. After 1 year follow-up, the patient achieved at least 50% pain relief, with no signs of lead displacement or resistance during flexion and extension movements of the involved upper limb, illustrating the success of PNFS.
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http://dx.doi.org/10.1080/17581869.2025.2463875 | DOI Listing |
Cells
February 2025
Department of Anesthesiology, University of California, San Diego, CA 92093, USA.
A significant portion of adolescents suffer from mental illnesses and persistent pain due to repeated stress. The components of the nervous system that link stress and pain in early life remain unclear. Prior studies in adult mice implicated the innate immune system, specifically Toll-like receptors (TLRs), as critical for inducing long-term anxiety and pain-like behaviors in social defeat stress (SDS) models.
View Article and Find Full Text PDFJ Appl Biomater Funct Mater
March 2025
Kerman Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Peripheral nerve tissue engineering is a field that uses cells, growth factors and biological scaffold material to provide a nutritional and physical support in the repair of nerve injuries. The specific properties of injectable human amniotic membrane-derived hydrogel including growth factors as well as anti-inflammatory and neuroprotective agents make it an ideal tool for nerve tissue repair, and metformin may also aid in nerve regeneration. The aim of this study was to investigate the effects of hydrogel derived from amniotic membrane (AM) along with metformin (MET) administration in the repair of sciatic nerve injury in male rats.
View Article and Find Full Text PDFBackground: Osseointegration (OI) has revolutionized prosthetic rehabilitation for amputees. Despite its contributions, postamputation pain remains a significant problem. This study aims to investigate the role of sciatic nerve regenerative peripheral nerve interface (RPNI) in patients undergoing transfemoral OI, focusing on its impact on pain and prosthetic wear.
View Article and Find Full Text PDFJ Med Life
January 2025
Discipline of Anatomy, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
The celiac ganglia are a network of nerve fibers that regulate various functions related to digestion, while the celiac trunk is a major artery that supplies oxygenated blood to the stomach, small intestine, and other organs in the upper abdominal region. Anatomical variants of these structures are common and can have significant implications for surgical and medical procedures. This prospective observational study was conducted over one year and included 300 patients (aged 45-75 years) with a history of peripheral arterial disease, evaluated at Dr.
View Article and Find Full Text PDFOncol Lett
April 2025
Department of Orthopedics, The First Clinical Medical College, Guangdong Medical University, Zhanjiang, Guangdong 524023, P.R. China.
Schwannomas are rare benign neoplasms originating from Schwann cells of peripheral nerve sheaths. The current study presents a distinctive case involving multiple schwannomas along the peripheral nerves of the left upper extremity. The patient exhibited multiple gradually enlarging subcutaneous masses distributed along the nerves of the left upper limb, without pain, neurological deficits or a positive Tinel's sign upon physical examination.
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