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Natural deep eutectic solvent-based liquid phase microextraction in a 3D-Printed millifluidic flow cell for the on-line determination of thiabendazole in juice samples.
Anal Chim Acta
February 2025
Departamento de Medio Ambiente y Agronomía, INIA-CSIC, Carretera de A Coruña km. 7.5, 28040, Madrid, Spain. Electronic address:
Background: At present, 3D printing technology is becoming increasingly popular in analytical chemistry because it enables the rapid and cost-effective manufacture of sample preparation devices, particularly in flow-based operation, opening up new opportunities for the development of automated analytical methods. In parallel, the use of miniaturized methods and sustainable solvents in sample preparation is highly recommended. Accordingly, in this work, a 3D-printed millifluidic device was designed and used for the on-line natural deep eutectic solvent (NADES)-based liquid phase microextraction (LPME) coupled to a spectrofluorometer for, as a proof of concept, the determination of thiabendazole (TBZ) in fruit juice samples.
View Article and Find Full Text PDFProgress in Tandem Mass Spectrometry Data Analysis for Nucleic Acids.
Mass Spectrom Rev
January 2025
Department of Chemistry, University of Texas at Austin, Austin, Texas, USA.
Mass spectrometry (MS) has become a critical tool in the characterization of covalently modified nucleic acids. Well-developed bottom-up approaches, where nucleic acids are digested with an endonuclease and the resulting oligonucleotides are separated before MS and MS/MS analysis, provide substantial insight into modified nucleotides in biological and synthetic nucleic. Top-down MS presents an alternative approach where the entire nucleic acid molecule is introduced to the mass spectrometer intact and then fragmented by MS/MS.
View Article and Find Full Text PDFRepackable microfluidic molecularly imprinted solid-phase extraction coupled with mass spectrometry (μMISPE-MS) for rapid analysis of mycotoxin in agri-foods: an example of zearalenone.
Lab Chip
January 2025
Department of Food Science and Agricultural Chemistry, McGill University Macdonald Campus, Sainte-Anne-de-Bellevue, Quebec, H9X 3V9, Canada.
Mycotoxins are detectable in 60-80% of food crops, posing significant threats to human health and food security, and causing substantial economic losses. Most mitigation approaches focus on detecting mycotoxins with standard methods based on liquid chromatography coupled with mass spectrometry (LC-MS). Typical MS methods require extensive sample preparation and clean-up due to the matrix effect, followed by time-consuming LC separation, complicating the analysis process and limiting analytical throughput.
View Article and Find Full Text PDFAutomated high-resolution 3D inspection methods for sealant applications in aerospace based on line structured light.
Rev Sci Instrum
January 2025
School of Electronic Engineering, Heilongjiang University, Harbin, HeiLongJiang 150080, China.
Gluing is a critical step in aircraft sealing assembly, with glue profile inspection serving as the final quality assurance measure to ensure consistency and accuracy of the sealant coating, allowing timely detection and correction of defects to maintain assembly integrity and safety. Currently, existing glue inspection systems are limited to basic inspection capabilities, lack result digitization, and exhibit low efficiency. This paper proposes a 3D inspection technology for sealant coating quality based on line-structured light, enabling automated and high-precision inspection of sealant thickness, sealant width, positional accuracy, and overlap joint sealant contour through geometric computation.
View Article and Find Full Text PDFA versatile and automatic on-line screening method: Transverse diffusion of laminar flow profiles-based capillary electrophoresis for exploring PTP1B inhibitors in natural products.
J Chromatogr A
January 2025
KU Leuven - University of Leuven, Pharmaceutical Analysis, Department of Pharmaceutical and Pharmacological Sciences, O&N2, PB 923, Herestraat 49 3000 Leuven, Belgium. Electronic address:
Natural products (NPs) play an important role in drug discovery and drug development due to their diverse chemical properties and biological activities. In the present work, an on-line capillary electrophoresis (CE) method was developed and applied to screen protein tyrosine phosphatase 1B (PTP1B) inhibitors in NPs. As a generic technique, transverse diffusion of laminar flow profiles (TDLFP) was utilized to mix all reactants in the capillary for on-line enzymatic reaction.
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