The self-administration of meloxicam via medicated feed is a novel concept that could enable non-invasive, pre-emptive and long-term analgesia. Forty male calves were randomly allocated to four treatment groups: no castration (PC), surgical castration (NC), surgical castration with subcutaneous meloxicam (M), and surgical castration with medicated lick blocks (ML). Data collection occurred at various timepoints over 13 days following treatment. Plasma concentration of meloxicam was greater in ML compared to M calves at all timepoints except day 1 ( < 0.001); however, variation between ML individuals was high (standard deviation = 1.68). There was no effect of treatment on scrotal diameter or scrotal temperature. Wound morphology scores were improved in ML compared to NC calves. Eating observations were greater in ML calves immediately post-castration, followed by M calves at 3 h post-castration ( < 0.001). ML calves were observed locomoting more ( = 0.0032) and lying less ( < 0.001) than PC calves. These findings indicate that meloxicam-medicated lick blocks may provide a practical option for a longer duration of pain mitigation for surgically castrated calves. Conclusions are limited by the complexities of assessing pain in cattle, and further research into the toxicity effects of continued administration of meloxicam is recommended.
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http://dx.doi.org/10.3390/ani15030442 | DOI Listing |
Animals (Basel)
February 2025
Sydney School of Veterinary Science, Faculty of Science, The University of Sydney, Sydney, NSW 2006, Australia.
The self-administration of meloxicam via medicated feed is a novel concept that could enable non-invasive, pre-emptive and long-term analgesia. Forty male calves were randomly allocated to four treatment groups: no castration (PC), surgical castration (NC), surgical castration with subcutaneous meloxicam (M), and surgical castration with medicated lick blocks (ML). Data collection occurred at various timepoints over 13 days following treatment.
View Article and Find Full Text PDFPhysiol Behav
October 2024
Departments of Psychiatry, New York University Grossman School of Medicine, 435 East 30th Street, New York, NY 10016, USA; Departments of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, 435 East 30th Street, New York, NY 10016, USA. Electronic address:
It was previously shown in striatal slices obtained from male rats that insulin excites cholinergic interneurons and increases dopamine (DA) release via α4β2 nicotinic receptors on DA terminals. The effect of insulin on DA release was blocked either by maintaining rats on a high sugar-high fat (HS-HF) diet that induced hyperinsulinemia and nucleus accumbens (NAc) insulin receptor insensitivity, or applying the α4β2 antagonist DHβE. In vivo, NAc shell insulin inactivation decreased a glucose lick microstructure parameter indicative of hedonic impact in male and female rats, and prevented flavor-nutrient learning, tested only in males.
View Article and Find Full Text PDFAnat Histol Embryol
July 2024
Department of Histology and Embryology, Faculty of Medicine, Kafkas University, Kars, Turkey.
This is the first study to describe the subtypes, number and distribution of mast cells (MC) in cat tongue by histochemical and immunohistochemical methods. Six male adult felines' tongue tissue samples consist of the study's material. Samples were fixed in 10% formaldehyde.
View Article and Find Full Text PDFbioRxiv
August 2023
Max Planck Florida Institute for Neuroscience, Jupiter, FL 33458, USA.
Neocortical spiking dynamics control aspects of behavior, yet how these dynamics emerge during motor learning remains elusive. Activity-dependent synaptic plasticity is likely a key mechanism, as it reconfigures network architectures that govern neural dynamics. Here, we examined how the mouse premotor cortex acquires its well-characterized neural dynamics that control movement timing, specifically lick timing.
View Article and Find Full Text PDFVet Med Sci
September 2023
Department of Animal Science, Bonga University, Bonga, Ethiopia.
Background: The major feedstuffs (natural pasture and crop residues) used for sheep in Ethiopia are fibrous and the crude protein (CP) content is less than 7% that is inadequate to meet the maintenance requirement of sheep. These poor quality feeds should be improved and can be improved through supplementation with nutritious feedstuff. Therefore, to overcome this challenge, there is a need to look for some alternatives but locally available and cheap sources of protein.
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