The Role of the Functionalization of Biomedical Fabrics on Their Ability to Adsorb and Release Drugs.

Biomedical cotton gauzes (), after a first functionalization with glycidyl methacrylate (GMA) by a Fenton's reaction (material ), can be further modified in order to make them suitable for the adsorption and next release of drugs. Indeed, either after opening the epoxide ring through the addition of water (material ) or after the introduction of amino groups through reaction with diamines (1,2-diaminoethane (material ), 1,6-diaminohexane (material ) and 1,12-diaminododecane (material )), the new gauzes can be uploaded with drugs. Both ibuprofen (IB), a non-steroidal anti-inflammatory, and amoxicillin (AM), a wide-spectrum β-lactam antibiotic, are efficiently adsorbed from their aqueous solutions at 20 °C onto - (up to ≈0.8 mmol g for IB and up to 0.4 mmol g for AM) but not onto and . The release of both IB and AM is affected by the ionic strength of the medium in which the release takes place. Indeed, kinetic experiments conducted with a physiological solution (NaCl (aq, 0.9% /) showed good release efficiencies while only modest or negligible release was observed if deionised water was the release medium. Moreover, the kind of functionalization plays an important role during both the adsorption and the release. The gauzes - can be uploaded with a higher amount of drug relative to . Conversely, the drug is released quickly and in a higher amount from relative to the gauzes containing the amino groups.