Exploring the Relationship Between Knowledge, Attitudes, Self-Efficacy, and Infection Control Practices Among Saudi Arabian Nurses: A Multi-Center Study.

Healthcare-associated infections are a significant risk to patients and the healthcare system. Differences in knowledge, attitudes, and practices among nurses have limited standardized precautions. Improving self-efficacy can enhance compliance with standard precautions, protect patients, and preserve the credibility of healthcare institutions. This study aimed to determine the mediating effects of self-efficacy on nurses' knowledge, attitude, and compliance with standard precautions in Saudi Arabia. This cross-sectional study was conducted in four hospitals in Dharan, Saudi Arabia, between July and October 2023. The respondents were selected through a multistage sampling of 305 nurses from wards and special areas. participants demonstrated a moderate level of knowledge (M = 19.00, SD = 2.17), positive attitudes (M = 55.86, SD = 10.22), intermediate compliance (M = 72.44, SD = 11.47), and moderate self-efficacy (M = 29.99, SD = 11.40). Respondents who possessed more knowledge demonstrated positive attitudes toward standard precautions (r = 0.256, < 0.001) and were more likely to comply (r = 0.376, < 0.001). Higher self-efficacy levels were significantly positively correlated with knowledge (r = 0.391, < 0.001), attitude (r = 0.311, < 0.001), and compliance (r = 0.385, < 0.001). The direct effect of knowledge on compliance was estimated to be 0.115 ( < 0.001), while the direct effect of attitude was slightly weaker (0.014, = 0.049). Self-efficacy indirectly increased compliance through its influence on knowledge and attitude, with indirect effects of 0.039 ( < 0.001) and 0.008 ( = 0.002), respectively. Nurses with higher knowledge of infection control and positive attitudes toward established protocols were more likely to comply consistently. This association is further strengthened by self-efficacy. This confidence enhanced their understanding of the specific procedures, reinforced their positive beliefs about the importance of protocols, and ultimately led to greater adherence.