Road markings, such as lane dividers and pedestrian crossings, are integral in ensuring the safety of road users. However, traditional markings frequently exhibit limitations, including short lifespans, diminished visibility, and significant maintenance costs, particularly as traffic volumes increase. To address these persistent challenges, this study presents a thermoplastic road marking system that combines material innovation and advanced application techniques. Central to this approach is the portable heating system, equipped with ceramic heaters and precise temperature controls, which facilitates uniform heating while mitigating fire risks. The thermoplastic blend, processed into pre-formed sheets, was integrated with this heating technology. Together, these components enabled a two-phase process, engraving asphalt surfaces followed by sheet integration, that ensured robust adhesion and seamless bonding. Field trials conducted on various asphalt types validated the system's reliability, demonstrating its durability under traffic loads and consistent visibility. By integrating durable materials with advanced application methods, this methodology significantly enhances the efficiency, longevity, and safety of road markings. It presents a practical and scalable solution for modern infrastructure needs. Future research will focus on evaluating the system's long-term performance under extreme weather conditions to further optimize its applicability.
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http://dx.doi.org/10.3390/polym17030361 | DOI Listing |
Cells
February 2025
Institute of Molecular Medicine, National Tsing Hua University, No. 101, Section 2, Kuang-Fu Road, Hsinchu 300044, Taiwan.
Brain injuries can result from accidents, warfare, sports injuries, or brain diseases. Identifying regeneration-associated genes (RAGs) during epigenome remodeling upon brain injury could have a significant impact on reducing neuronal death and subsequent neurodegeneration for patients with brain injury. We previously identified several WNT genes as RAGs involved in the neurite regrowth of injured cortical neurons.
View Article and Find Full Text PDFChem Soc Rev
March 2025
Department of Chemistry, The University of Manchester, Oxford Road, Manchester, M13 9PL, UK.
Whilst bis(trimethylsilyl)amide has been used extensively as a ligand across the periodic table, the chemistry of its heavier group 15 congeners is relatively underdeveloped. However, bis(trimethylsilyl)phosphide coordination chemistry has provided unique structural motifs and has also shown potential applications in catalysis, materials science, and bioinorganic chemistry. This review, which marks 55 years since the first report of a bis(trimethylsilyl)phosphide complex, provides a comprehensive overview of the synthesis, characterisation and reactivity of structurally authenticated s-, p-, d- and f-block metal complexes of this ligand, focusing on salient single crystal XRD and NMR spectroscopic data.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
March 2025
Jiangnan University, School of Food Science and Technology, CHINA.
Sensitive and specific biomarkers are needed for early diagnosis of neurodegenerative diseases, such as Alzheimer's disease (AD). Herein, a new type of chiral gold nanostructure induced by D-/L-cysteine-leucine dipeptides with a g-factor of 0.1 was successfully synthesized.
View Article and Find Full Text PDFActa Neuropathol Commun
March 2025
Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.
Identifying protein deposits and associated components is crucial for understanding the pathogenesis of neurodegenerative disorders with intracellular or extracellular deposits. Correlative light and electron microscopy (CLEM) has emerged as a powerful tool to accurately study tissue and cellular pathology by examination of the same target at both microstructural and ultrastructural levels. However, the technical challenges with CLEM have limited its application to neuropathology.
View Article and Find Full Text PDFCancer Lett
March 2025
370 Heritage Medical Research Center, Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB T6G 2S2. Canada. Electronic address:
p53, often referred to as the "guardian of the genome," is a critical regulator of cellular responses to stress. p53 plays a dual role in tumor suppression and immune regulation. In addition to its well-known functions of maintaining genomic stability and inducing apoptosis, p53 orchestrates a complex interaction between innate and adaptive immune responses.
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