Polyethylene (PE) is a widely used material for packaging food. However, certain additives and their degradation products, which may be generated during transformation processes, may pose risks to consumers health if they migrate into food at levels exceeding safety thresholds. Therefore, identifying and quantifying these potential migrant compounds is crucial to ensuring consumer safety. In the present work, PE films and the raw materials used in their production were kindly provided by the industry to evaluate undesired compounds throughout the PE transformation chain. For that purpose, volatile and semi-volatile organic compounds were evaluated using gas chromatography coupled to mass spectrometry (GC-MS). Alkanes were identified as the most abundant compounds, along with antioxidants, lubricants, or Non-Intentionally Added Substances (NIAS), like 7,9-di-tert-butyl-1-oxaspiro(4,5)deca-6,9-diene-2,8-dione in the films. For the unidentified compounds, evaluations were conducted at various stages of the transformation chain, and migration assays were performed to assess their behavior.
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http://dx.doi.org/10.3390/polym17030295 | DOI Listing |
ACS Chem Neurosci
March 2025
Department of Pharmacology, University of Michigan, Ann Arbor, Michigan 48109, United States.
Bispecific antibodies (bAbs) that engage cerebrovascular targets, induce transport across the blood-brain barrier (BBB), and redistribute to secondary targets within the brain parenchyma have the potential to transform the diagnosis and treatment of a wide range of central nervous system disorders. Full understanding of the pharmacokinetics (PK) of these agents, including their potential for delivering cargo into brain parenchymal cells, is a key priority for the development of numerous potential therapeutic applications. To date, the brain PK of bAbs that target transferrin receptor (TfR-1) and CD98 heavy chain (CD98hc) has been characterized using techniques incapable of distinguishing between CNS clearance of intact protein from uptake and catabolism by brain parenchymal cells.
View Article and Find Full Text PDFChem Commun (Camb)
March 2025
State Key Laboratory of Metastable Material Science and Technology, School of Information Science and Engineering, Yanshan University, Qinhuangdao, Hebei 066004, China.
A solvent/temperature dual-responsive P(NIPAM-AM) hydrogel is proposed. The free energy model of the hydrogel microstructure and the transformation of the properties of the hydrogel chain segment during deformation were further analyzed. The resultant structural-color hydrogel film was applied to on-demand patterning.
View Article and Find Full Text PDFAm J Health Syst Pharm
March 2025
Houston Methodist West Hospital, Houston, TX, USA.
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View Article and Find Full Text PDFOrg Lett
March 2025
Institute of Next Generation Matter Transformation, College of Material Sciences Engineering, Huaqiao University, Xiamen, Fujian 361021, China.
An expedient synthesis of α-aminoboronic acid derivatives via cobalt-catalyzed remote site-selective hydroboration of unactivated alkenes is described herein. The strategy is characterized by its simplicity, site-selectivity, and wide substrate scope, as both terminal and internal alkenes could undergo the reaction smoothly, affording the corresponding products in good yields. According to the mechanism, Co-H is generated from Co(acac) in the presence of HBpin, which starts the chain-walking strategy via a series of alkene insertion and β-H elimination process.
View Article and Find Full Text PDFPharmacol Rep
March 2025
Department of Animal Physiology and Pharmacology, Institute of Biological Sciences, Maria Curie-Skłodowska University, Akademicka 19, 20-033, Lublin, Poland.
Background: A number of rodent studies have investigated the effects of alcohol (ethanol) administration on the catecholaminergic neurotransmitters, norepinephrine (NE) and dopamine (DA). These studies suggest that presentation of alcohol to mice or rats can alter brain levels of NE and DA, in various subregions. Other studies have presented the hypothesis that there may be an unidentified pathway in rodents, and other organisms, that actually transforms ethanol to NE or DA.
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