Esophageal squamous cell carcinoma (SCC) is a highly lethal malignancy with a low survival rate, often presenting at an advanced stage. Cutaneous metastasis from esophageal SCC is exceedingly rare, affecting less than 1 % of cases, and is associated with a poor prognosis. This review particularly focuses on facial metastasis and discusses the clinical presentation, diagnostic challenges, and management of cutaneous metastases. The variability in clinical presentation often leads to misdiagnosis, delaying appropriate treatment. Histopathological examination and immunohistochemical staining are crucial for accurate diagnosis. Management involves a combination of local and systemic therapies, tailored to the patient's overall health and disease extent. This topic emphasizes the need for vigilance and thorough diagnostic workups in patients with unusual skin lesions and highlights the importance of multidisciplinary care in optimizing treatment outcomes for patients with advanced esophageal cancer.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.amjms.2025.02.003 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
An Exceptional Case of Garcin Syndrome Mimicking Bell's Palsy in Advanced Non-Small Cell Lung Carcinoma.
Indian J Otolaryngol Head Neck Surg
February 2025
Department of Otorhinolaryngology, Head and Neck Surgery, Hospital Canselor Tuanku Muhriz, Universiti Kebangsaan Malaysia, Cheras, Malaysia.
Garcin syndrome is an exceptional clinical condition characterized by progressive multiple ipsilateral cranial nerve involvement which is caused by malignant osteoclastic lesion at skull base. We report a rare case of Garcin syndrome which was misdiagnosed as Bell's palsy. A 69-year-old lady, presented with generalized headache and right facial nerve palsy in which progressively worsened even after treatment with corticosteroid.
View Article and Find Full Text PDFCYP2A6 suppresses hepatocellular carcinoma via inhibiting SRC/Wnt/β-Catenin pathway.
Acta Pharmacol Sin
March 2025
Department of Pharmacology, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Ji-nan, 250012, China.
Patients with hepatocellular carcinoma (HCC) at advanced stages face limited treatment options, highlighting the urgent need for more effective early detection methods and advanced therapeutic modalities. Emerging evidence shows that multiple CYP450 proteins are involved in the pathogenesis of HCC. CYP1A2, CYP2E1 and CYP3A5 have been shown to modulate important signaling pathways, hereby inhibiting the proliferation and invasion of HCC cells.
View Article and Find Full Text PDFCase report: A study on the pathology of mandibular osteosarcoma with hepatic metastasis in a giant panda.
Front Vet Sci
February 2025
Experimental Animal Disease Model Research Laboratory, School of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
During routine health examinations, an abnormal growth was detected in the oral cavity of a male giant panda. A malignant tumor, osteosarcoma, was diagnosed through CT (computed tomography) scans and pathological examination of biopsy samples. After two attempts at "tumor reduction surgery" with no improvement, the condition stabilized following particle implantation and arterial infusion interventional therapy.
View Article and Find Full Text PDFWell-Differentiated Liposarcoma in the Left Face.
J Craniofac Surg
March 2025
People's Hospital of Rizhao, Rizhao.
Liposarcoma is the most prevalent malignant neoplasm originating from mesenchymal tissues, accounting for ~25% of soft tissue sarcomas in adults. It typically occurs in the trunk, limbs, retroperitoneum, and other anatomical regions, while its occurrence in the facial area is relatively rare. Here, the authors present a case involving an Asian male patient who presented to the Department of Dermatology and Cosmetic Surgery at our hospital with a subcutaneous mass located on the left side of the face.
View Article and Find Full Text PDFFactors influencing clinical decision-making and health-related quality of life changes in colorectal cancer patients receiving targeted therapy: a multicenter study in China.
BMC Cancer
March 2025
Department of Cancer Epidemiology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, 127 Dongming Road, Zhengzhou, 450008, China.
Objectives: The aim of this paper is to assess the current clinical application of targeted therapy in colorectal cancer (CRC), identify factors influencing patients' acceptance of targeted therapy, and evaluate its impact of targeted therapy on patients' health-related quality of life (HRQoL).
Methods: This study was based on a national multi-center survey. From March 2020 to March 2021, involved 19 tertiary hospitals across seven regions in China through multi-stage stratified sampling.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!