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Single-centre, randomised and double-blind clinical trial on the efficacy of transcutaneous auricular vagus nerve stimulation in preventing and treating primary headache in children and adolescents: a study protocol.
BMJ Open
March 2025
Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China
Introduction: Primary headaches pose a significant burden on children and adolescents, highlighting the need for effective non-pharmacological interventions. Transcutaneous auricular vagus nerve stimulation (taVNS) is a non-invasive modality that has demonstrated efficacy in adult populations with primary headaches and has shown safety in adolescents with mental health disorders. However, its effectiveness in managing acute headache episodes and preventing recurrences in paediatric populations remains underexplored.
View Article and Find Full Text PDFA Controlled Trial for Preventing Priapism in Sickle Cell Anemia: Hydroxyurea plus Placebo vs Hydroxyurea plus Tadalafil.
Blood
March 2025
Vanderbilt UniversityVanderbilt-Meharry Center of Excellence in Sickle Cell Disease, Nashville, Tennessee, United States.
Recurrent ischemic priapism is a common complication of sickle cell anemia (SCA) and is associated with devastating physical and psychosocial consequences. All previous trials for priapism prevention have failed to demonstrate clear efficacy. We conducted a randomized, controlled, double-blind phase 2 feasibility trial comparing fixed moderate-dose hydroxyurea plus placebo (usual care arm) versus fixed moderate-dose hydroxyurea plus tadalafil (experimental arm) in 64 men (18- 40 years) with at least three episodes of SCA-related priapism in the past 12 months.
View Article and Find Full Text PDFCathodal Transcranial Direct Current Stimulation Does Not Change Implicit Associations Against Alcohol in Alcohol Use Disorder: A Preregistered Clinical Trial.
Addict Biol
March 2025
Department of Psychiatry and Psychotherapy, Neurophysiology and Interventional Neuropsychiatry, University of Tübingen, Tübingen, Germany.
Addictive behaviour is shaped by the dynamic interaction of implicit, bottom-up and explicit, top-down cognitive processes. In alcohol use disorder (AUD), implicit alcohol-related associations have been shown to predict increased subsequent alcohol consumption and are linked to the risk of relapse. Explicit cognitive processes, exerting prefrontal top-down control, are particularly significant during the critical period following the decision to abstain.
View Article and Find Full Text PDFLaser Irradiation and Property Correlation in Double-Lasing Processes on Laser-Induced Graphene Electrodes.
Nanomaterials (Basel)
February 2025
Department of Chemistry, Research Institute for Basic Sciences, Kyung Hee University, Seoul 02447, Republic of Korea.
The fabrication of laser-induced graphene (LIG) electrodes by direct laser writing techniques has received considerable attention due to its simplicity, versatility, and cost-effectiveness for electrochemical applications in both sensing and energy storage. In general, a single-lasing irradiation process is used to prepare LIG electrodes. However, the intrinsic features of LIG can be further improved by taking advantage of additional lasing processes, even without any chemical treatments.
View Article and Find Full Text PDFLaparoscopic repair of uterine rupture after delivery: A comprehensive evaluation of the uterine rupture management, with a proposal surgical method.
Int J Gynaecol Obstet
March 2025
Department of Obstetrics and Gynecology, and CERICSAL (CEntro di RIcerca Clinico SALentino), "Veris delli Ponti" Hospital, Lecce, Italy.
Uterine rupture constitutes a critical obstetric emergency that presents substantial risks to both the maternal and fetal populations. This investigation evaluated the surgical interventions available for uterine rupture, emphasizing laparoscopic repair subsequent to uterine rupture. Laparoscopic repair serves as a fertility-sustaining alternative to conventional laparotomy, demonstrating comparable operative durations of 80 min (interquartile range [IQR] 60-114) for laparoscopic procedures versus 78 min (IQR 58-114) for laparotomy interventions.
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