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A case of a neonatal cardiac tumor with ventricular tachycardia undergoing emergency surgery.
BMC Pediatr
February 2025
Department of Electrical Biology, Henan Children's Hospital, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital Zhengzhou Children's Hospital, Zhengzhou, 450018, China.
Background: Cardiac tumors in children are rare and usually have no obvious clinical symptoms. However, a small number of children may experience serious conditions such as arrhythmia, heart obstruction, and even death. When severe arrhythmia cannot be controlled by conservative treatment, surgical intervention is needed.
View Article and Find Full Text PDFCardiovascular Toxicity Profile of Macrolides Investigated Using VigiBase Data: A Pharmacovigilance Study.
Cardiovasc Toxicol
March 2025
Department of Clinical Pharmacology and Therapeutics, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto, Tokushima, 770-8503, Japan.
Macrolides are associated with cardiovascular toxicity risk. However, data on their cardiovascular toxicity profiles beyond QT prolongation are limited, and differences in the profiles among various macrolide antibiotics remain unclear. We investigated the cardiovascular toxicity profiles of different macrolides using VigiBase, a global database of individual case-safety reports.
View Article and Find Full Text PDFLandiolol is effective and safe in paediatric supraventricular tachycardia: evidence from a European prospective multicentre open-label phase III study (LANDI-PED).
Europace
February 2025
Board of Directors, AOP Health International Management AG, Ruggell, Liechtenstein.
Aims: Landiolol, an ultra-fast acting super-selective beta-blocker, was investigated for the first time in Europe in a prospective clinical study for the management of supraventricular tachycardia (SVT) among paediatric patients.
Methods And Results: The LANDI-PED study was a prospective, multicentre, open-label, uncontrolled phase III study aiming to investigate the efficacy, safety, and pharmacokinetics (PK) of landiolol in paediatric patients. Sixty patients in surgical and non-surgical settings aged ≥1 day to <18 years with SVTs of various aetiologies received landiolol as a continuous intravenous infusion starting with 5 μg/kg/min titrated up to 40 μg/kg/min depending on heart rate (HR) reduction for up to a maximum of 24 h.
Neonatal Supraventricular Tachycardia- The Bedside Ultrasound Unearths Hidden Bullets.
Indian J Pediatr
February 2025
Department of Pediatric Surgery, Manipal Hospital, Bangalore, Karnataka, India.
Cardiac Regenerative Potential of Spiny Mice (Acomys cahirinus) Manifests Itself in Expansion of Pacemaker Myocardium and Predominance of Noncanonical, I-Independent Pathway of Cholinergic Regulation in Cardiac Pacemaking.
Dokl Biol Sci
January 2025
Chazov National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation, Moscow, Russia.
Spiny mice (Acomys cahirinus) exhibit the ability to regenerate the damaged myocardium and functional indices of the heart. demonstrated in various models of cardiac pathologies. Cardioregenerative potential of Acomys is associated with partial preservation of the neonatal phenotype of cardiac tissue in adult animals.
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