Large fires in the western United States become highly probable when dry conditions surpass critical thresholds of vapor pressure deficit (VPD). VPD likely differs between human- and lightning-ignited fires, potentially leading to ignition-type varied responses of fire weather risk to natural variability and various anthropogenic forcings, yet a comprehensive quantification remains lacking. Here, through fire observations with ignition types and a machine learning method, we found that human-ignited large fires had consistently lower thresholds (VPD) across western US ecoregions. Consequently, the annual number of flammable days (when VPD > VPD) for human-caused large fires was 93% higher on average and increased 21% more rapidly than those caused by lightning during 1979-2020. Through robust statistical detection and attribution of Earth System Models, we found that the anthropogenic greenhouse gas (GHG) emissions predominantly (81%) controlled the human-related flammable day increases, which was 18% greater than the effect of GHGs on the increases in lightning-related flammable days. Such ignition-type varied fire weather risk indicates more large fire-prone conditions for human-regulated fire regimes when GHG emissions are enhancing and ignitions are not limited by fuels.
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http://dx.doi.org/10.1093/pnasnexus/pgaf012 | DOI Listing |
BJPsych Open
March 2025
Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK.
Background: Women's authorship position in science, technology, engineering, mathematics and medicine research reflects career progression, especially the transition from first to last (usually senior) author. Employment of women in mental health sciences has increased, and so should have had an impact on the change to senior author position.
Aims: To identify if first or last women's authorship has changed, and mental health has better representation.
Elife
March 2025
Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, Netherlands.
Human autonomic neuronal cell models are emerging as tools for modelling diseases such as cardiac arrhythmias. In this systematic review, we compared thirty-three articles applying fourteen different protocols to generate sympathetic neurons and three different procedures to produce parasympathetic neurons. All methods involved the differentiation of human pluripotent stem cells, and none employed permanent or reversible cell immortalization.
View Article and Find Full Text PDFActa Physiol (Oxf)
April 2025
Department of Physiology, Faculty of Medicine, Yeditepe University, Istanbul, Turkey.
Aim: Mitochondria play key roles in neuronal activity, particularly in modulating agouti-related protein (AgRP) and proopiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus (ARC), which regulates food intake. FAM163A, a newly identified protein, is suggested to be part of the mitochondrial proteome, though its functions remain largely unknown. This study aimed to investigate the effects of Fam163a knockdown and mitochondrial dysfunction on food intake, AgRP neuron activity, and mitochondrial function in the hypothalamus.
View Article and Find Full Text PDFVaccine
March 2025
Medical Evidence, Vaccines & Immune Therapies, BioPharmaceuticals Medical, AstraZeneca, Cambridge, UK.
Background: Booster doses of COVID-19 vaccines are required to maintain protection against SARS-CoV-2. However, real-world evidence from South America, needed to inform optimal vaccination strategies, is lacking. Herein, we present the final analysis of REFORCO-Brazil, a large-scale assessment of relative vaccine effectiveness (rVE) of second boosters (vs first boosters) against hospitalization with COVID-19.
View Article and Find Full Text PDFAm J Ophthalmol
March 2025
Moorfields Eye Hospital NHS Foundation Trust, London, UK; NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust & UCL Institute of Ophthalmology, London, UK.
Objective: To identify genetic determinants specific to reticular pseudodrusen (RPD) compared with drusen.
Design: Genome-wide association study (GWAS) SUBJECTS: Participants with RPD, drusen, and controls from the UK Biobank (UKBB), a large, multisite, community-based cohort.
Methods: A deep learning framework analyzed 169,370 optical coherence tomography (OCT) volumes to identify cases and controls within the UKBB.
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