Given the widespread interest and ongoing study on MDMA-assisted therapy (MDMA-AT) for PTSD, its implications for unique populations-such as adolescents-require further understanding. Social workers will likely play a crucial role in the potential implementation of this intervention, but their perspectives remain unknown. The study includes 222 social workers randomized to read one of two vignettes about MDMA-AT or selective serotonin reuptake inhibitor-assisted therapy (SSRI-AT) for treating adolescent treatment-resistant PTSD. Participants rated each treatment's acceptability, appropriateness, and feasibility, followed by drug stigma, perceptions of drug risk, and psychedelic knowledge. Participants in the SSRI-AT condition reported significantly higher mean ratings of treatment acceptability (p < .001; d = .72), appropriateness (p < .001; d = .72), and feasibility (p < .001; d =. 64). In the MDMA-AT condition, perceptions of MDMA risk were greater (p < .001; d = .59) and psychedelic stigma positively correlated with perceived risk of MDMA (r = .46, p < .001). Moreover, greater psychedelic knowledge was significantly related to less stigma (r = -.33, p < .001) and less perceived risk of MDMA (r = -.21, p < .001). Concerns among social workers about the acceptability, appropriateness, and feasibility of MDMA-AT for adolescents with PTSD may limit clinical trial recruitment, engagement, and future implementation.
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