Background: Childhood cancer has become a pressing global concern, impacting over 200,000 children annually, and is projected to escalate to 21 million diagnoses by 2030. This article discusses the growing incidence of pediatric cancer in India, describes the unique obstacles it faces, and encompasses a strategy for solving this pressing problem.
Methods: We reviewed published scientific literature and available information on cancer control and prevention programs in India.
Results: According to the National Cancer Registry Programme, in India, childhood cancers (0-14 years) constitute 4.0% of all cancer cases. The surge in childhood cancer cases in India mirrors a global trend, emphasizing the necessity for a comprehensive understanding of contributing factors. Pediatric oncology in India faces challenges arising from limited rural healthcare access, resulting in delayed diagnosis and treatment. Socioeconomic factors hinder specialized pediatric cancer care, accentuating the need to bridge these gaps through targeted interventions, improved infrastructure, and policies. Additionally, there are limited population-level epidemiologic studies on environmental, lifestyle, and genetic risk factors and childhood cancers. Research on genetic and environmental determinants is crucial for developing effective treatments. Addressing this requires public education, enhanced medical and research training, community-based cancer screening, and integrated medical care initiatives. Advocacy and awareness campaigns play a vital role in tackling pediatric cancer challenges, supported by grassroots initiatives and collaboration between the government and nongovernmental organizations.
Conclusion: Despite recent efforts by the Ministry of Health, Government of India, childhood cancer lacks a specific policy in India. Urgent collective efforts are needed to address challenges, invest in research, enhance awareness, and advocate for policy changes. It is time for healthcare professionals, policymakers, researchers, and the public to collaborate and ensure no child in India is left behind in the fight against pediatric cancer, paving the way for a healthier future for the nation's youngest members.
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http://dx.doi.org/10.1002/hsr2.70429 | DOI Listing |
J Allergy Clin Immunol
March 2025
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minn. Electronic address:
Background: The few reported patients with pathogenic IRF8 variants have manifested 2 distinct phenotypes: (1) an autosomal recessive severe immunodeficiency with significant neutrophilia and absence of or significant decrease in monocytes and dendritic cells and (2) a dominant-negative form with only a decrease in conventional type 2 dendritic cells (cDC2s) and susceptibility to mycobacterial disease.
Objectives: Genetic testing of a child with persistent EBV viremia identified a novel IRF8 variant: c.1279dupT (p.
Genes Chromosomes Cancer
March 2025
Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Sex cord-stromal tumors are rare in pediatric patients. Leydig cell tumors are a rare subset of sex cord-stromal tumors characterized by unique molecular alterations, including TERT fusions and mutations of CTNNB1, FOXO4, TP53, NBN, MTOR, BAP1, MEN1, and CREBBP. We report a case of a testicular Leydig cell tumor with an EWSR1::CREM fusion, which to our knowledge has not been previously reported in this setting.
View Article and Find Full Text PDFCells
February 2025
Department of Gastroenterology and Internal Medicine, Medical University of Bialystok, 15-276 Bialystok, Poland.
An association between gut microbiota and the development of pancreatic ductal adenocarcinoma (PDAC) has been previously described. To better understand the bacterial microbiota changes accompanying PDAC promotion and progression stimulated by inflammation and fecal microbiota transplantation (FMT), we investigated stool and pancreatic microbiota by 16s RNA-based metagenomic analysis in mice with inducible acinar transgenic expressions of KrasG12D, and age- and sex-matched control mice that were exposed to inflammatory stimuli and fecal microbiota obtained from mice with PDAC. Time- and inflammatory-dependent stool and pancreatic bacterial composition alterations and stool alpha microbiota diversity reduction were observed only in mice with a Kras mutation that developed advanced pancreatic changes.
View Article and Find Full Text PDFNeuro Oncol
March 2025
Kids Cancer Centre, Sydney Children's Hospital, Randwick, NSW, Australia.
Background: Factors that drive the development of diffuse midline gliomas (DMG) are unknown. Our study aimed to determine the prevalence of pathogenic/likely pathogenic (P/LP) germline variants in pediatric patients with DMG.
Methods: We assembled an international cohort of 252 pediatric patients with DMG, including diffuse intrinsic pontine glioma (n=153), with germline whole genome or whole exome sequencing.
Eur J Immunol
March 2025
Department of Immunology, Assistance Publique- Hôpitaux de Paris (AP-HP), Georges Pompidou European Hospital, Paris, France.
Inborn deficiencies of the alternative pathway (AP) of the complement system have been associated with life-threatening infections, mainly by encapsulated bacteria. Complete factor D (FD) deficiencies have been reported in only seven families in the literature. We report two new cases of biochemically and genetically confirmed complete FD deficiency, including the first in a Down syndrome patient.
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