Boredom is the feeling of wanting but failing to engage the mind and can be conceived as one among many signals of suboptimal utilization of cognitive and neural resources. Using homeostasis as an analogy, this perspective argues that boredom represents a signal indicating deviation from optimal engagement-that is, deviation from a cognitive homeostatic set point. Within this model, allostasis accounts for chronic boredom (i.e., trait boredom proneness), according to which faulty internal models are responsible for why the highly boredom prone may set unrealistic expectations for engagement. In other words, the model characterizes boredom as a dynamic response to both internal and external exigencies, leading to testable hypotheses for both the nature of the state and the trait disposition. Furthermore, this perspective presents the broader notion that humans strive to optimally engage with their environs to maintain a kind of cognitive homeostatic set-point.
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http://dx.doi.org/10.1038/s44271-025-00209-6 | DOI Listing |
PLoS One
March 2025
Sleep Research Institute, Edogawa University, Nagareyama, Japan.
Interoception refers to the sensation of internal and physiological bodily states, such as heart rate, and contributes to the maintenance of bodily internal homeostasis. Some studies showed that interoceptive awareness is related to experiencing nightmares and subjective sleep quality. Similarly to the perception of heart rate variability, sleepiness is thought to be mainly evoked by homeostatic processes and is based on the awareness and recognition of internal body signals.
View Article and Find Full Text PDFSci Rep
March 2025
Department of Biomedical Engineering, Yale University, New Haven, CT, USA.
Despite extensive research on neuroimaging correlates of human brain aging, there is little mechanistic insight into how they are linked to loss of brain function. Previous studies on the role of cerebral blood flow (CBF) in supporting brain function have focused on delivery of nutrients, namely oxygen and glucose. However, CBF is required also to clear the byproducts of energy metabolism, namely CO and protons.
View Article and Find Full Text PDFJ Physiol
February 2025
Laboratoire des Systèmes Perceptifs, Département d'études Cognitives, École Normale Supérieure, PSL University, CNRS, Paris, France.
Homeostatic and Hebbian plasticity co-operate during the critical period, refining neuronal circuits; however, the interaction between these two forms of plasticity is still unclear, especially in adulthood. Here, we directly investigate this issue in adult humans using two consolidated paradigms to elicit each form of plasticity in the visual cortex: the long-term potentiation-like change of the visual evoked potential (VEP) induced by high-frequency stimulation (HFS) and the shift of ocular dominance induced by short-term monocular deprivation (MD). We tested homeostatic and Hebbian plasticity independently, then explored how they interacted by inducing them simultaneously in a group of adult healthy volunteers.
View Article and Find Full Text PDFNature
February 2025
Stanford Chemistry, Engineering and Medicine for Human Health (ChEM-H), Stanford University, Stanford, CA, USA.
The blood-brain barrier (BBB) is highly specialized to protect the brain from harmful circulating factors in the blood and maintain brain homeostasis. The brain endothelial glycocalyx layer, a carbohydrate-rich meshwork composed primarily of proteoglycans, glycoproteins and glycolipids that coats the BBB lumen, is a key structural component of the BBB. This layer forms the first interface between the blood and brain vasculature, yet little is known about its composition and roles in supporting BBB function in homeostatic and diseased states.
View Article and Find Full Text PDFJ Neurochem
February 2025
Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
Astrocytes are glial cells recognized for their diverse roles in regulating brain circuit structure and function. They can sense and adapt to changes in the microenvironment due to their unique structural and biochemical properties. A key aspect of astrocytic function involves calcium (Ca)-dependent signaling, which serves as a fundamental mechanism for their interactions with neurons and other cells in the brain.
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