Lymphatic filariasis (LF) is a parasitic neglected tropical disease (NTD) that can lead to debilitating conditions such as lymphoedema (elephantiasis) and hydrocele, impacting affected individuals' quality of life and economic productivity by interfering with their physical and psychological health. Like most countries, Kenya established its National Programme to Eliminate Lymphatic Filariasis in 2000. It launched its first Mass Drug Administration (MDA) in Kilifi District in 2002, with subsequent expansions to Kwale, Malindi, Tana River, Lamu, and Mombasa counties in Kenya's coastal region. This is despite documenting its first case in 1910, with high antigenemia and microfilariae prevalence reported by most studies conducted in the pre-program period. MDA was implemented intermittently from 2000 to 2015 due to limited resources to treat all at-risk individuals. However, since 2016, the country has implemented continuous and successive MDA campaigns, which have contributed to a significant reduction in disease prevalence based on the results of transmission and impact surveys conducted so far. Therefore, it is plausible to envisage that the country is on track toward eliminating LF as a public health problem in Kenya by 2030.
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http://dx.doi.org/10.1016/j.ijid.2025.107839 | DOI Listing |
Front Public Health
March 2025
Department of Nursing, College of Health Science, Mattu University, Mattu, Ethiopia.
Background: Podoconiosis is non-filarial lymphoedema of the lower extremities. It impairs individuals' overall lives, including their health, economy, psychology, and social interactions. Podoconiosis is a preventable and effectively manageable disease.
View Article and Find Full Text PDFPLoS Negl Trop Dis
March 2025
Department of Pathology, Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio, United States of America.
Background: Persons with lymphatic filariasis (LF) are often co-infected with soil-transmitted helminths. A single co-administered dose of ivermectin/diethylcarbamazine/albendazole (IDA) is recommended by WHO for mass drug administration (MDA) for LF instead of diethylcarbamazine/albendazole (DA) in Papua New Guinea (PNG). We compared the effectiveness of a single round of MDA with IDA or DA on hookworm and strongyloidiasis in PNG.
View Article and Find Full Text PDFInt J Infect Dis
March 2025
International Society for Infectious Diseases; S.H. Ho Research Centre for Infectious Diseases, The Chinese University of Hong Kong, Shatin, Hong Kong.
After detection of 2 clinical lymphatic filariasis (LF) cases in a postelimination context in 2023 on the island of Futuna (Wallis and Futuna archipelago), the Wallis and Futuna Health Agency conducted a LF prevalence survey in Futuna in May 2024. This cross-sectional study, carried out among schoolchildren <18 years of age, identified 5 children with antigenemia, indicating an estimated antigenemia prevalence in Futuna children nearing 2%. The study also confirmed a spatial cluster of cases in the village of Taoa, where the child antigenemia prevalence reached 7.
View Article and Find Full Text PDFInt J Biol Macromol
February 2025
Protein Structure-Function and Research Unit, School of Molecular and Cell Biology, Faculty of Science, University of the Witwatersrand, Braamfontein, Johannesburg, 2050, South Africa. Electronic address:
Wuchereria bancrofti glutathione transferase (WbGST) is a therapeutic target in the parasitic worms that cause lymphatic filariasis. We described the molecular and structural basis of WbGST inhibition by Bromosulphophthalein (BSP) and compared it with human Mu (hGSTMu) and Pi (hGSTPi) class GSTs. BSP inhibited WbGST activity with an IC of 5 μM, 13.
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