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Spatial Distribution of Brain PET Tracers by MALDI Imaging.
J Am Soc Mass Spectrom
March 2025
The Maastricht MultiModal Molecular Imaging Institute (M4i), Division of Imaging Mass Spectrometry, Maastricht University, Universiteitssingel 50, 6229 ER Maastricht, The Netherlands.
Evaluating tissue distribution of Positron Emission Tomography (PET) tracers during their development conventionally involves autoradiography techniques, where radioactive compounds are used for visualization and quantification in tissues during preclinical development stages. Mass Spectrometry Imaging (MSI) offers a potential alternative, providing spatial information without the need for radioactivity with a similar spatial resolution. This study aimed to optimize a MSI sample preparation protocol for assessing PET tracer candidates with a focus on two compounds: UCB-J and UCB2400.
View Article and Find Full Text PDFEmerging PET radiotracers for vascular imaging.
Rheumatology (Oxford)
March 2025
Section of Cardiorespiratory Medicine, Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.
Imaging plays an important role in the clinical management of patients with large-vessel vasculitis (LVV), both to confirm the diagnosis at the time of initial presentation and to identify disease relapses in individuals with established disease. The big advantage of PET imaging over other non-invasive imaging modalities is the ability to employ targeted radionuclide probes to localize and track cellular pathways, providing in vivo assessments of disease activity. While 18F-fluorodeoxyglucose (FDG) has good diagnostic accuracy for LVV, this tracer is taken up by all glucose metabolizing cells in the vessel wall and so non-specific arterial uptake that is often unrelated to inflammatory disease activity can occur in patients despite a good clinical response to treatment.
View Article and Find Full Text PDFAn NRF2/β3-Adrenoreceptor Axis Drives a Sustained Antioxidant and Metabolic Rewiring Through the Pentose-Phosphate Pathway to Alleviate Cardiac Stress.
Circulation
March 2025
Institute of Experimental and Clinical Research (IREC), Pharmacology and Therapeutics (FATH), Cliniques Universitaires St. Luc and Université catholique de Louvain, Brussels, Belgium (L.Y.M.M., H.E., D.d.M., R.V., N.F., J.-L.B.).
Background: Cardiac β3-adrenergic receptors (ARs) are upregulated in diseased hearts and mediate antithetic effects to those of β1AR and β2AR. β3AR agonists were recently shown to protect against myocardial remodeling in preclinical studies and to improve systolic function in patients with severe heart failure. However, the underlying mechanisms remain elusive.
View Article and Find Full Text PDFRadiosynthesis, Characterization, and PET Neuroimaging of [F]F-4 for Tau Protein: A First-in-Human PET Study.
ACS Chem Neurosci
March 2025
Azrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, CAMH, Toronto M5T 1R8, Canada.
[F]PI-2620 is a promising radiopharmaceutical for positron emission tomography (PET) imaging of both Alzheimer's disease (AD) and non-Alzheimer's disease (non-AD) tauopathies in humans. An array of fluorinated derivatives of the carbazole scaffold of PI-2620 were synthesized and evaluated. binding assays with [H]PI-2620 in human tissues with AD, progressive supranuclear palsy, and corticobasal degeneration, combined with predictions of blood-brain barrier permeability, led to the selection and radiosynthesis of [F]F-4 as a promising radiotracer.
View Article and Find Full Text PDFTargeted imaging of pulmonary fibrosis by a cyclic peptide LyP-1.
Sci Rep
March 2025
School of Basic Medical Science, Medical Science Research Center, Zhongnan Hospital, Wuhan University, Wuhan, China.
Pulmonary fibrosis (PF) is an interstitial chronic lung disease characterized by interstitial inflammation and extracellular matrix deposition, resulting in progressive lung dysfunction and ultimate respiratory failure. However, lacking of precise and noninvasive tracers for fibrotic lesions limits timely diagnosis and treatment. Here, we identified LyP-1, a cyclic peptide, as a specific and sensitive tracer for PF detection using PET/CT imaging.
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