Objective: Management of postoperative pain in pediatric patients is challenging. Traditional methods of postoperative pain management may not always provide adequate relief. We aim to compare the effect of Quadratus Lumborum Block (QLB) and Transversus Abdominis Plane Block (TAPB) on the quality of postoperative analgesia in pediatrics undergoing lower abdominal surgeries.
Methods: We systematically searched PubMed, Scopus, Web of Science, and Cochrane Library up to August 2024 for studies that compared QLB and TAPB in the context of pediatric lower abdominal surgery. Pooled mean difference (MD), standardized mean difference (SMD), and odds ratio (OR) were calculated by a random effect model using RevMan 5.4.
Results: Nine studies met the pre-defined inclusion criteria. Pooled analysis indicated that postoperative pain measured by the FLACC score was lower in the QLB group compared to the TAPB group (MD: -0.37; 95% CI: -0.51, -0.23; P < 0.00001). QLB was also associated with lower rescue analgesic demand (OR: 0.25; 95% CI, 0.13, 0.49; P < 0.0001), higher parent satisfaction (SMD: 0.78; 95% CI: 0.53, 1.02; P < 0.00001), longer time without the need for analgesic administration (MD: 1.04; 95% CI: 0.38, 1.71; P = 0.002), and lower paracetamol consumption (SMD: -1.40; 95% CI: -2.43, -0.36; P = 0.008). However, no significant difference was found in terms of postoperative nausea, vomiting, and heart rate.
Conclusion: QLB provides superior analgesia compared to TAPB in pediatrics undergoing lower abdominal surgeries.
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http://dx.doi.org/10.2147/JPR.S502044 | DOI Listing |
Front Nutr
February 2025
Universidade Federal de Pernambuco - UFPE, Recife, Brazil.
Background: Abdominal adipose tissue consists of visceral and subcutaneous fat deposits, each with unique metabolic and functional properties. Identifying the characteristics that influence different obesity phenotypes can support targeted prevention and intervention strategies.
Objective: To identify predictive factors associated with visceral and subcutaneous adipose tissue accumulation.
Eur J Anaesthesiol
March 2025
From the Department of Anaesthesiology, Intensive Care and Emergency Medicine, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy (AR, PA, LC, LSM, BR, SC, EC, FP, CC, MA, LS, AMDA), the Department of Basic Biotechnological Science, Intensive and Peri-operative Clinics, Università Cattolica del Sacro Cuore, Rome, Italy (PA, CF, SA, MA, LA).
Background: Arterial hypotension during major surgery is related to postoperative complications and mortality. Both fluids and vasopressors increase blood pressure (BP) by inducing different physiological response. We devised a protocol which relies on dynamic arterial elastance (Eadyn) to guide BP optimisation during major abdominal surgery, and tested its effectiveness on tissue perfusion.
View Article and Find Full Text PDFDiabetes Obes Metab
March 2025
Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München, University of Leipzig and University Hospital Leipzig, Leipzig, Germany.
Obesity is a highly prevalent chronic multisystem disease associated with shortened life expectancy due to a number of adverse health outcomes. Epidemiological data link body weight and parameters of central fat distribution to an increasing risk for type 2 diabetes, hypertension, fatty liver diseases, cardiovascular diseases including myocardial infarction, heart failure, atrial fibrillation, stroke, obstructive sleep apnoea, osteoarthritis, mental disorders and some types of cancer. However, the individual risk to develop cardiometabolic and other obesity-related diseases cannot entirely be explained by increased fat mass.
View Article and Find Full Text PDFCancer Imaging
March 2025
Radiology, Department of Surgical Sciences, Uppsala University, Uppsala University Hospital, entry 70, 1st floor, Uppsala, 751 85, Sweden.
Background: Non-small cell lung cancer (NSCLC) is a common neoplasm with poor prognosis in advanced stages. The clinical work-up in patients with locally advanced NSCLC mostly includes F-fluorodeoxyglucose positron emission tomography computed tomography (F-FDG PET/CT) because of its high sensitivity for malignant lesion detection; however, specificity is lower. Diverging results exist whether whole-body MRI (WB-MRI) improves the staging accuracy in advanced lung cancer.
View Article and Find Full Text PDFBMC Gastroenterol
March 2025
The Forth Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, 730000, Gansu, China.
Objective: To investigate whether preoperative biliary drainage is beneficial for patients undergoing pancreaticoduodenectomy.
Methods: The PubMed, Cochrane Library and the Web of Science were systematically searched for relevant trials that included outcome of pancreaticoduodenectomy with and without preoperative biliary drainage from January 2010 to May 2024. The primary outcomes are postoperative pancreatic fistula and intra-abdominal infection.
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