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| http://dx.doi.org/10.3389/fimmu.2025.1533086 | DOI Listing |
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Antibody responses in Burkinabe children against proteins associated with reduced risk of clinical malaria.
Front Immunol
March 2025
Division of Malaria Research, Proteo-Science Center, Ehime University, Matsuyama, Japan.
Individuals residing in malaria-endemic regions with high disease transmission can develop semi-immunity within five years of age. Although understanding the target of the IgGs in this age group helps discover novel blood-stage vaccine candidates and serological markers, it has not been well elucidated due to limited accessibility to plasmodial antigens and samples. This study presents the first comprehensive analysis of antibody levels in plasma obtained from Burkinabe children (n=80, aged 0 to 5 years) to 1307 proteins expressed by the eukaryotic wheat germ cell-free system.
View Article and Find Full Text PDFAssociation between SARS-CoV-2 infection and anti-apolipoprotein A-1 antibody in children.
Front Immunol
March 2025
Department of Pediatrics, Gynecology and Obstetrics, Faculty of Medicine, Geneva, Switzerland.
Background And Aims: Autoantibodies against apolipoprotein A-1 (AAA1) are elicited by SARS-CoV-2 infection and predict COVID-19 symptoms persistence at one year in adults, but whether this applies to children is unknown. We studied the association of SARS-CoV-2 exposure with AAA1 prevalence in children and the association of AAA1 seropositivity with symptom persistence.
Methods: Anti-SARS-CoV-2 and AAA1 serologies were examined in 1031 participants aged 6 months to 17 years old from the prospective SEROCOV-KIDS cohort and recruited between 12.
Cross-protectivity of henipavirus soluble glycoprotein in an model of Nipah virus disease.
Front Immunol
March 2025
Specialised Microbiology and Laboratories, United Kingdom Health Security Agency (UKHSA), Salisbury, Wiltshire, United Kingdom.
Introduction: Nipah virus (NiV) is one of a group of highly pathogenic viruses classified within the Henipavirus genus. Since 2012 at least 11 new henipa-like viruses have been identified, including from new locations and reservoir hosts; the pathogenicity of these new viruses has yet to be determined, but two of them have been associated with morbidity, including fatalities.
Methods: The efficacy and cross-reactivity of two vaccine candidates derived from the soluble glycoproteins of both NiV and Hendra virus (HeV) was evaluated in our recently established hamster model.
Editorial: Allergen-specific antibodies: from basic science to clinical application.
Front Allergy
February 2025
Basic Research, InBio, Charlottesville, VA, United States.
Modulation of Immune Responses by Metabolic Reprogramming: The Key Role of Immunometabolism.
Immune Netw
February 2025
Department of Life Science, Sogang University, Seoul 04107, Korea.
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