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[Merkel cell carcinoma: An update].
Bull Cancer
March 2025
Dermatologie, CHU de Tours, Tours, France; Réseau CARADERM, France.
Merkel cell carcinoma (MCC) is a rare skin cancer that mainly affects the elderly, and whose incidence is increasing. Although the exact origin of this cancer remains uncertain, research in recent years has revealed that MCC develops through two oncogenesis pathways: virally induced by the Merkel polyomavirus (80% of cases) and induced by mutations linked to ultraviolet rays (20% of cases). MCC is an aggressive cancer, with a high mortality rate and limited therapeutic options in advanced stage.
View Article and Find Full Text PDF[Evaluation of Reproducibility in Left Breast Deep Inspiration Breath-hold Irradiation Using Quantitative Assessment Software].
Nihon Hoshasen Gijutsu Gakkai Zasshi
March 2025
Department of Radiology, Osaka Red Cross Hospital.
Purpose: We developed software that can analyze central lung distance (CLD) and central skin distance (CSD) in deep inspiration breath hold (DIBH) irradiation and verified the reproducibility of the DIBH irradiation method in our hospital.
Methods: CLD and CSD were analyzed using In-house software using cine images acquired during treatment; intra- or inter-fractional motion was calculated from the obtained data and compared with other reports using systematic error (ΔΣ) and random error (Δσ).
Results: The ΔΣ and Δσ were 1.
Blue rubber bleb nevus syndrome: A case report and literature review.
Zhong Nan Da Xue Xue Bao Yi Xue Ban
October 2024
Department of Radiology, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Blue rubber bleb nevus syndrome (BRBNS) is a rare congenital clinical syndrome characterized by venous malformations in multiple organs, including the skin, gastrointestinal tract, liver, and lungs. In June 2022, Third Xiangya Hospital of Central South University admitted a rare case of BRBNS. The patient was hospitalized due to abdominal distension and a history of recurrent hematochezia.
View Article and Find Full Text PDFImproved survival at the population level for patients with advanced Merkel cell carcinoma following availability of immunotherapy.
J Am Acad Dermatol
March 2025
Fred Hutchinson Cancer Center, Seattle, WA; University of Washington, Seattle, WA. Electronic address:
Background: Merkel cell carcinoma (MCC) is an aggressive skin cancer with poor survival rates. Immune checkpoint inhibitors (ICIs) were FDA-approved for advanced MCC in 2017, but their real-world survival impact remains unclear.
Objective: Evaluate whether ICI introduction in the US corresponded with improved survival.
In-transit melanoma metastases: Evaluation and Management for the Dermatologist.
J Am Acad Dermatol
March 2025
Mayo Clinic, Department of Dermatology, Rochester, MN, USA. Electronic address:
In-transit metastases (ITM) are estimated to occur in 5-10% of primary cutaneous melanomas. They are classified as stage III disease in the American Joint Committee on Cancer classification system and are associated with approximately a 30% 10-year survival rate. The management of ITM is not standardized.
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