Background: The evolution of medical standards in stigmatized areas like abortion is influenced by medical, political, and social factors. Self-sourcing and managing medication abortion (SSMA) is on the rise in the United States, where individuals obtain medications to end their pregnancies outside traditional medical settings. Physician attitudes towards SSMA are not well understood, despite physicians' role in setting care standards, providing medical oversight, and de-stigmatizing healthcare both within and outside clinical environments.
Materials And Methods: We interviewed 40 physicians (MD/DOs) who perform abortions about their views on SSMA. We used inductive-deductive coding for transcript analysis and qualitatively assessed how attitudes shifted before and during the interviews.
Results: Most participants were aged 31-35 years (n = 16, 40%), non-Hispanic White (n = 29, 72.5%), and female (n = 33, 82.5%). We oversampled family medicine-trained physicians (n = 31, 78%) compared to OB/GYNs (n = 9, 22.5%). Participants were from 24 states, with half from states supporting abortion rights and the other half from states with hostile or neutral stances. Half of the cohort supported SSMA, while the other half was ambivalent. Medical evidence alone did not sway physician views on SSMA; instead, participants adjusted their attitudes by clarifying their professional values, evaluating SSMA's alignment with these values, and considering values-based frameworks as alternatives to medicalization.
Discussion: Although medical care is typically seen as objective and standardized, physicians' ethics to ensure safe access to care often clash with political restrictions in this stigmatized field. Physicians are more worried about the broader structural issues related to SSMA, such as how political and social vulnerabilities could harm the most vulnerable patients, rather than the medical care itself, which they see as safe and effective, with or without physician oversight. Positive attitudes toward SSMA were strengthened by exposure to values-based frameworks that offer alternatives to strict medicalization.
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http://dx.doi.org/10.1016/j.socscimed.2025.117708 | DOI Listing |
Magn Reson Med
March 2025
Center for Magnetic Resonance Research, Radiology, Medical School, University of Minnesota, Minneapolis, Minnesota, USA.
Purpose: To propose a two-step, nonlocal principal component analysis (PCA) method and demonstrate its utility for denoising complex diffusion MR images with a few diffusion directions.
Methods: A two-step denoising pipeline was implemented to ensure accurate patch selection even with high noise levels and was coupled with data preprocessing for g-factor normalization and phase stabilization before data denoising with a nonlocal PCA algorithm. At the heart of our proposed pipeline was the use of a data-driven optimal shrinkage algorithm to manipulate the singular values in a way that would optimally estimate the noise-free signal.
J Cell Sci
March 2025
Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
Mitochondria perform diverse functions, such as producing ATP through oxidative phosphorylation, synthesizing macromolecule precursors, maintaining redox balance, and many others. Given this diversity of functions, we and others have hypothesized that cells maintain specialized subpopulations of mitochondria. To begin addressing this hypothesis, we developed a new dual-purification system to isolate subpopulations of mitochondria for chemical and biochemical analyses.
View Article and Find Full Text PDFNeurol Neurochir Pol
March 2025
Department of Neurosurgery, Medical University of Gdansk, Gdansk, Poland.
Introduction: This study aimed to identify predictive factors for long-term incomplete nidus obliteration following stereotactic radiosurgery (SRS) for brain arteriovenous malformations (AVMs).
Material And Methods: A systematic search across the PubMed, Web of Science, and Scopus databases identified observational studies reporting such factors. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed.
J Chem Theory Comput
March 2025
Department of Chemistry, Iowa State University, Ames, Iowa 50011, United States.
Protein evolution has shaped enzymes that maintain stability and function across diverse thermal environments. While sequence variation, thermal stability and conformational dynamics are known to influence an enzyme's thermal adaptation, how these factors collectively govern stability and function across diverse temperatures remains unresolved. Cytosolic malate dehydrogenase (cMDH), a citric acid cycle enzyme, is an ideal model for studying these mechanisms due to its temperature-sensitive flexibility and broad presence in species from diverse thermal environments.
View Article and Find Full Text PDFJ Ment Health
March 2025
School of Social Work, Arizona State University, Phoenix, AZ, USA.
Background: Media portrayals inform understandings of mental illness; yet little research has investigated representations of characters with psychosis in fictional television programming.
Aims: This study examined the valence and trends regarding representations of people with psychosis in popular fictional television programing in the United States, one of the most influential markets in the world.
Methods: A content analysis was conducted of the 50 most-watched American primetime fictional television shows from 2011 to 2021.
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