With the development of society and economy, Non-alcoholic fatty liver disease (NAFLD) has gradually affected people's health. It is very important to find an effective treatment for NAFLD. Salusin-α is a kind of cardiovascular active peptide that can reduce blood pressure and slow down the heart rate. Studies have shown that Salusin-α can inhibit the development of atherosclerosis by regulating lipid metabolism. However, whether Salusin-α can inhibit the lipid accumulation of C57BL/6 mice with NAFLD has not been reported. Our study found that Salusin-α ameliorated lipid accumulation of NAFLD mice. Salusin-α has a good prospect in the treatment of NAFLD.
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http://dx.doi.org/10.1016/j.bbrc.2025.151452 | DOI Listing |
Immune Netw
February 2025
Laboratory of Immune Regulation, Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Korea.
The importance of mitochondrial function in macrophages is well established. Alveolar macrophages (AMs), the tissue-resident macrophages (TRMs) of the lung, are particularly dependent on mitochondria-driven oxidative phosphorylation (OXPHOS) to support their functions and maintain homeostasis. However, the specific genes and pathways that regulate OXPHOS in AMs remain unclear.
View Article and Find Full Text PDFHortic Res
April 2025
School of Ecology and Environment, Northwestern Polytechnical University, 1 Dongxiang Road, Changan District, Xi'an 710129, China.
Plant epicuticular waxes (EW) play a critical role in defending against biotic and abiotic stresses. Notably, onions () present a distinctive case where the mutant with defect in leaf and stalk EW showed resistance to thrips compared with the wild type with integral EW. We identified a premature stop codon mutation in the gene, an ortholog of gene in that has been proved essential for the biosynthesis of very long-chain fatty acids (VLCFAs), in the onions with glossy leaf and stalks in our experiments.
View Article and Find Full Text PDFJ Clin Transl Hepatol
March 2025
Department of Gastroenterology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Background And Aims: The transcription factor sex-determining region Y-related high-mobility group-box gene 9 (SOX9) plays a critical role in organ development. Although SOX9 has been implicated in regulating lipid metabolism , its specific role in metabolic dysfunction-associated steatohepatitis (MASH) remains poorly understood. This study aimed to investigate the role of SOX9 in MASH pathogenesis and explored the underlying mechanisms.
View Article and Find Full Text PDFMol Omics
March 2025
Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Due to their self-renewal and differentiation capabilities, pluripotent stem cells hold immense potential for advancing our understanding of human disease and developing cell-based or pharmacological interventions. Realizing this potential, however, requires a thorough understanding of the basal cellular mechanisms which occur during differentiation. Lipids are critical molecules that define the morphological, biochemical, and functional role of cells.
View Article and Find Full Text PDFLiver Int
April 2025
Laboratory of Molecular Biology of Exercise, University of Campinas (UNICAMP), Limeira, Sao Paulo, Brazil.
Background And Aims: Notch1 protein plays a significant role in hepatic metabolism, as evidenced by its correlation with insulin resistance in the livers of obese individuals, making it an intriguing research target. Therefore, this study aims to investigate the impact of aerobic exercise on Notch1 pathways in the hepatic tissue of obese mice and its role in controlling hepatic metabolism.
Methods: Therefore, we conducted a cross-sectional study utilising liver biopsies from lean and obese humans, as well as an intervention study involving mice subjected to a high-fat diet.
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