Objective: Several factors (e.g., interpersonal stress, affect) predict loss-of-control (LOC) eating and overeating in adolescents, but most past research has tested predictors separately. We applied machine learning to simultaneously evaluate multiple possible predictors of LOC-eating and overeating severity in pooled and person-specific models.
Method: Twenty-eight adolescents (78.57% female, age = 15.87 ± 1.59 years, BMI %ile = 92.71 ± 8.86) who endorsed ≥ two past-month LOC-eating episodes completed a week-long ecological momentary assessment protocol. Pooled models were fit to the aggregated data with elastic-net regularized regression and evaluated using nested cross-validation. Person-specific models were fit and evaluated as proof-of-concept.
Results: Across adolescents, the median out-of-sample R of the pooled LOC-eating severity model was .33. The top predictors were between-subjects food craving, sadness, interpersonal conflict, shame, distress, stress (inverse association), and anger (inverse association), and within- and between-subjects wishing relationships were better. The median out-of-sample R for pooled overeating severity model was .20. The top predictors were between-person food craving, loneliness, mixed race, and feeling rejected (inverse association), and within-subjects guilt, nervousness, wishing for more friends (inverse association), and feeling scared, annoyed, and rejected (all inverse associations). Person-specific models demonstrated poor fit (median LOC-eating severity R = .003, median overeating R = -.009); 61% and 36% of adolescents' models performed better than chance for LOC-eating and overeating severity, respectively.
Discussion: Altogether, group-level models may hold utility in predicting LOC-eating and overeating severity, but model performance for person-specific models is variable, and additional research with larger samples over an extended assessment period is needed. Ultimately, a mix of these approaches may improve the identification of momentary predictors of LOC eating and overeating, providing novel and personalized opportunities for intervention.
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http://dx.doi.org/10.1016/j.appet.2025.107900 | DOI Listing |
Front Med (Lausanne)
February 2025
Longgang District Maternity & Child Healthcare Hospital of Shenzhen City (Longgang Maternity and Child Institute of Shantou University Medical College), Shenzhen, China.
encodes a nuclear protein, with functions in pre-mRNA splicing and the formation of nuclear speckles via liquid-liquid phase separation. Despite its critical role in cellular function, the association between and neurodevelopmental disorders is not well-understood. In this study, we reported a case of a patient exhibiting developmental delay, intellectual disability, delayed language development, facial dysmorphism, macrocephaly, short hands and feet, hyperphagia, and hypotonia, which are similar to the characteristics of previously reported cases of SRRM2-associated neurodevelopmental disorders.
View Article and Find Full Text PDFNutrients
February 2025
Department of Psychology, Trinity University, San Antonio, TX 78212, USA.
: Evidence suggests that food insecurity (FI) is a risk factor for eating disorder (ED) symptoms, especially binge eating (BE), yet research focusing on the psychosocial effects among midlife/older women is lacking. Midlife/older women living with FI experience intersectional disadvantage, thus highlighting the need for an independent investigation of the cultural and contextual factors of this population. The current study examined the difference in psychological health and quality of life (QOL) among women living with BE and FI (BE + FI) versus FI without BE.
View Article and Find Full Text PDFJ Neurodev Disord
February 2025
Foundation for Prader-Willi Research, Covina, CA, USA.
Background: Prader-Willi syndrome (PWS), a genetic neurodevelopmental disorder, is characterized by hyperphagia and significant behavioral problems. Hyperphagic individuals with PWS are chronically hungry yet rarely feel sated, and often engage in food-seeking behaviors. To avoid life-threatening obesity in their children, families implement food security strategies (e.
View Article and Find Full Text PDFAppetite
March 2025
Department of Psychiatry, New York State Psychiatric Institute, Columbia University Irving Medical Center, New York, NY, USA; Department of Psychiatry, University of Buffalo, Buffalo, NY, USA. Electronic address:
Objective: Several factors (e.g., interpersonal stress, affect) predict loss-of-control (LOC) eating and overeating in adolescents, but most past research has tested predictors separately.
View Article and Find Full Text PDFEndocrinol Metab Clin North Am
March 2025
Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Obesity Medicine Program, University of Utah, Salt Lake City, UT 84108, USA. Electronic address:
Obesity-related genetic disorders are marked by severe, early-onset obesity caused by mutations that disrupt key biological mechanisms regulating hunger, energy balance, and fat storage. These disorders commonly impact systems such as the hypothalamic leptin-melanocortin signaling network, which plays a crucial role in controlling appetite and body weight, mainly through the melanocortin-4 receptor (MC4R) pathway. This review explores current management strategies and emerging therapies for genetic obesity disorders, highlighting the importance of treatment approaches and expanded genetic diagnostics to improve outcomes for affected individuals.
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