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Zona incerta: from Parkinson's disease to addiction.
Front Neural Circuits
February 2025
Inserm, U1216, Univ. Grenoble Alpes, Grenoble Institut Neurosciences, Grenoble, France.
The zona incerta regulates burying behavior and normalizes anxiety-like behavior in inescapable stressful male mice by object cue.
Neurobiol Stress
January 2025
Department of Radiology, Jinling Hospital, Medical School, Nanjing University, Nanjing, 210002, PR China.
Inescapable stressful events often precipitate long-term alterations in emotion-related behaviors and poor sleep quality, with anxiety being a prevalent associated disorder. The defensive burying behavior of rodents is a response to imminent threats that becomes markedly pronounced in response to anxiety. However, the neural foundations of defensive burying behavior and etiology of anxiety remain largely unknown.
View Article and Find Full Text PDFDevelopment of the early fetal human thalamus: from a protomap to emergent thalamic nuclei.
Front Neuroanat
February 2025
Newcastle University Biosciences Institute and Centre for Transformative Neuroscience, Newcastle upon Tyne, United Kingdom.
Introduction: Most of what is known about thalamic development comes from rodent studies, however, the increased proportion of human association cortex has co-evolved with increased thalamocortical connectivity. Higher order thalamic nuclei, relaying information between cortical regions and important in higher cognitive function, are greatly expanded.
Methods: This study mapped the emergence of thalamic nuclei in human fetal development (8-16 post conceptional weeks; PCW) by revealing gene expression patterns using in situ hybridization and immunohistochemistry for previously established thalamic development markers.
Sweet spot for resting-state functional MRI effect of deep brain stimulation in dystonia lies in the lower pallidal area.
Neuroimage Clin
February 2025
Department of Neurology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Kateřinská 30, 120 00 Prague, Czech Republic. Electronic address:
Introduction: Deep brain stimulation (DBS) of the internal globus pallidus (GPi) is a well-established, effective treatment for dystonia. Substantial variability of therapeutic success has been the one of the drivers of an ongoing debate about proper stimulation site and settings, with several indications of the notional sweet spot pointing to the lower GPi or even subpallidal area.
Methods: The presented patient-blinded, random-order study with cross-sectional verification against healthy controls enrolled 17 GPi DBS idiopathic, cervical or generalised dystonia patients to compare the effect of the stimulation in the upper and lower GPi area, with the focus on sensorimotor network connectivity and local activity measured using functional magnetic resonance.
Activation of zona incerta gamma-aminobutyric acid-ergic neurons alleviates depression-like and anxiety-like behaviors induced by chronic restraint stress.
World J Psychiatry
February 2025
Department of Psychiatry, Xiaogan Rehabilitation Hospital, Xiaogan 432000, Hubei Province, China.
Background: Depression is a prevalent affective disorder, but its pathophysiology remains unclear. Dysfunction in the gamma-aminobutyric acid (GABA)-ergic system may contribute to its onset. Recently, antidepressants ( brexanolone, zuranolone) targeting the GABA-A receptor were introduced.
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